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Noninvasive prediction of outcomes in autoimmune hepatitis-related cirrhosis

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dc.contributor.author Llovet, Laura-Patricia
dc.contributor.author Gratacós-Ginès, Jordi
dc.contributor.author Téllez, Luis
dc.contributor.author Gómez-Outomuro, Ana
dc.contributor.author Navascués, Carmen A.
dc.contributor.author Riveiro-Barciela, Mar
dc.contributor.author Vinuesa, Raquel
dc.contributor.author Gómez-Camarero, Judith
dc.contributor.author García-Retortillo, Montserrat
dc.contributor.author Díaz-Fontenla, Fernando
dc.contributor.author Salcedo, Magdalena
dc.contributor.author García-Eliz, María
dc.contributor.author Horta, Diana
dc.contributor.author Guerrero, Marta
dc.contributor.author Rodríguez-Perálvarez, Manuel
dc.contributor.author Fernández-Rodriguez, Conrado
dc.contributor.author Albillos, Agustín
dc.contributor.author Abraldes, Juan Gonzales
dc.contributor.author Parés Jiménez, Albert
dc.contributor.author Londoño, María-Carlota
dc.date.accessioned 2022-09-21T06:13:01Z
dc.date.available 2022-09-21T06:13:01Z
dc.date.issued 2022
dc.identifier.citation Llovet LP, Gratacós-Ginès J, Téllez L, Gómez-Outomuro A, Navascués CA, Riveiro-Barciela M, Vinuesa R, Gómez-Camarero J, García-Retortillo M, Díaz-Fontenla F, Salcedo M, García-Eliz M, Horta D, Guerrero M, Rodríguez-Perálvarez M, Fernández-Rodriguez C, Albillos A, G-Abraldes J, Parés A, Londoño MC. Noninvasive prediction of outcomes in autoimmune hepatitis-related cirrhosis. Hepatol Commun. 2022 Jun;6(6):1392-402. DOI: 10.1002/hep4.1889
dc.identifier.issn 2471-254X
dc.identifier.uri http://hdl.handle.net/10230/54127
dc.description.abstract The value of noninvasive tools in the diagnosis of autoimmune hepatitis (AIH)-related cirrhosis and the prediction of clinical outcomes is largely unknown. We sought to evaluate (1) the utility of liver stiffness measurement (LSM) in the diagnosis of cirrhosis and (2) the performance of the Sixth Baveno Consensus on Portal Hypertension (Baveno VI), expanded Baveno VI, and the ANTICIPATE models in predicting the absence of varices needing treatment (VNT). A multicenter cohort of 132 patients with AIH-related cirrhosis was retrospectively analyzed. LSM and endoscopies performed at the time of cirrhosis diagnosis were recorded. Most of the patients were female (66%), with a median age of 54 years. Only 33%-49% of patients had a LSM above the cutoff points described for the diagnosis of AIH-related cirrhosis (12.5, 14, and 16 kPa). Patients with portal hypertension (PHT) had significantly higher LSM than those without PHT (15.7 vs. 11.7 kPa; P = 0.001), but 39%-52% of patients with PHT still had LSM below these limits. The time since AIH diagnosis negatively correlated with LSM, with longer time being significantly associated with a lower proportion of patients with LSM above these cutoffs. VNT was present in 12 endoscopies. The use of the Baveno VI, expanded Baveno VI criteria, and the ANTICIPATE model would have saved 46%-63% of endoscopies, but the latter underpredicted the risk of VNT. Conclusions: LSM cutoff points do not have a good discriminative capacity for the diagnosis of AIH-related cirrhosis, especially long-term after treatment initiation. Noninvasive tools are helpful to triage patients for endoscopy.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Hepatol Commun. 2022 Jun;6(6):1392-402
dc.rights © 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Noninvasive prediction of outcomes in autoimmune hepatitis-related cirrhosis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/hep4.1889
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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