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Mood disturbances, anxiety, and impact on quality of life in patients admitted to epilepsy monitoring units

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dc.contributor.author Rocamora Zúñiga, Rodrigo Alberto
dc.contributor.author Chavarría, Beatriz
dc.contributor.author Pérez, Eva
dc.contributor.author Pérez Enríquez, Carmen
dc.contributor.author Barguilla Arribas, Ainara
dc.contributor.author Panadés-de Oliveira, Luisa
dc.contributor.author Principe, Alessandro
dc.contributor.author Zucca, Riccardo
dc.date.accessioned 2022-07-29T06:46:35Z
dc.date.available 2022-07-29T06:46:35Z
dc.date.issued 2021
dc.identifier.citation Rocamora R, Chavarría B, Pérez E, Pérez-Enríquez C, Barguilla A, Panadés-de Oliveira L, et al. Mood disturbances, anxiety, and impact on quality of life in patients admitted to epilepsy monitoring units. Front Neurol. 2021 Oct 28; 12: 761239. DOI: 10.3389/fneur.2021.761239
dc.identifier.issn 1664-2295
dc.identifier.uri http://hdl.handle.net/10230/53889
dc.description.abstract Introduction: the overall combined prevalence of anxiety and depression in patients with epilepsy has been estimated at 20.2 and 22.9%, respectively, and is considered more severe in drug-refractory epilepsy. Patients admitted to epilepsy monitoring units constitute a particular group. Also, patients with psychogenic non-epileptic seizures can reach more than 20% of all admissions. This study aims to characterize these symptoms in a large cohort of patients admitted for evaluation in a tertiary epilepsy center. Materials and Methods: the study was conducted among 493 consecutive patients (age: 38.78 ± 12.7, 57% females) admitted for long-term video EEG from January 2013 to February 2021. Demographic, clinical, and mood disorder patients' data were collected. Anxiety and depression symptoms were assessed through the Hospital Anxiety Depression Scale (HADS-A and HADS-D), the State Trait Anxiety Inventory (STAI), and Beck Depression Inventory (BDI-II). Quality of life was determined using the QOLIE-10. Patients were divided into three groups: patients with epilepsy (n = 395), psychogenic non-epileptic seizures (PNES) (n = 56), and combined (n = 33). A univariate and multivariate regression analysis was performed for variables associated with quality of life. Results: of 493 patients, 45.0% had structural etiology, and considering epilepsy classification, 43.6% were of temporal lobe origin. In addition, 32.45% of patients had a previous psychiatric history, 49.9% of patients had depressive symptoms in BDI, and 30.9% according to HADS-D; 56.42 and 52.63% of patients presented pathological anxiety scores in STAI-T and STAI-S, respectively; and 44.78% according to HADS-A. PNES and combined groups revealed a higher incidence of pathologic BDI scores (64.29 and 78.79%, p < 0.001) as well as pathologic HADS-A scores (p = 0.001). Anxiety and depression pathologic results are more prevalent in females, HADS-A (females = 50.7%, males = 36.8%; p = 0.0027) and BDI > 13 (females = 56.6%, males = 41.0%; p = 0.0006). QOLIE-10 showed that 71% of the patients had their quality of life affected with significantly higher scores in the combined group than in the epilepsy and PNES groups (p = 0.0015). Conclusions: subjective anxiety, depression, and reduced quality of life are highly prevalent in patients with refractory epilepsy. These symptoms are more evident when PNES are associated with epilepsy and more severe among female patients. Most of the cases were not previously diagnosed. These factors should be considered in everyday clinical practice, and specific approaches might be adapted depending on the patient's profile.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.rights Copyright © 2021 Rocamora, Chavarría, Pérez, Pérez-Enríquez, Barguilla, Panadés-de Oliveira, Principe and Zucca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Mood disturbances, anxiety, and impact on quality of life in patients admitted to epilepsy monitoring units
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fneur.2021.761239
dc.subject.keyword Anxiety depression; epilepsy; epilepsy monitoring unit; quality of life
dc.subject.keyword Depression
dc.subject.keyword Epilepsy
dc.subject.keyword Epilepsy monitoring unit
dc.subject.keyword Quality of life
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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