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Respiratory and peripheral muscle weakness and body composition abnormalities in non-cystic fibrosis bronchiectasis patients: Gender differences

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dc.contributor.author Wang, Xuejie
dc.contributor.author Balañá Corberó, Ana, 1981-
dc.contributor.author Martínez-Llorens, Juana Mª
dc.contributor.author Qin, Liyun
dc.contributor.author Xia, Yingchen
dc.contributor.author Zha, Jianhua
dc.contributor.author Maiques LLacer, José María
dc.contributor.author Barreiro Portela, Esther
dc.date.accessioned 2022-07-28T14:59:11Z
dc.date.available 2022-07-28T14:59:11Z
dc.date.issued 2022
dc.identifier.citation Wang X, Balaña-Corberó A, Martínez-Llorens J, Qin L, Xia Y, Zha J, Maiques JM, Barreiro E. Respiratory and peripheral muscle weakness and body composition abnormalities in non-cystic fibrosis bronchiectasis patients: Gender differences. Biomedicines. 2022 Jan 31;10(2):334. DOI: 10.3390/biomedicines10020334
dc.identifier.issn 2227-9059
dc.identifier.uri http://hdl.handle.net/10230/53877
dc.description.abstract As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly altered in female than in males for identical age and disease severity. In mild-to-moderate bronchiectasis patients (n = 150, 114 females) and 37 controls (n = 37, 21 females), radiological extension, maximal inspiratory and expiratory pressures (MIP and MEP), sniff nasal inspiratory pressure (SNIP), hand grip and quadriceps muscle strengths, body composition, and blood analytical biomarkers were explored. Compared to the controls, in all bronchiectasis patients (males and females), BMI, fat-free mass index (FFMI), fat tissue, upper and lower limb muscle strength, and respiratory muscle strength significantly declined, and FFMI, fat tissue, and quadriceps muscle function were significantly lower in female than male patients. In patients with mild-to-moderate bronchiectasis, respiratory and peripheral muscle function is significantly impaired and only partly related to lung disease status. Quadriceps muscle strength was particularly weakened in the female patients and was negatively associated with their exercise tolerance. Muscle weakness should be therapeutically targeted in bronchiectasis patients. Body composition and peripheral muscle function determination should be part of the comprehensive clinical assessment of these patients.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Biomedicines. 2022 Jan 31;10(2):334
dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Respiratory and peripheral muscle weakness and body composition abnormalities in non-cystic fibrosis bronchiectasis patients: Gender differences
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/biomedicines10020334
dc.subject.keyword Bronchiectasis patients
dc.subject.keyword Differences between male and female patients
dc.subject.keyword Lower limb muscle function
dc.subject.keyword Muscle weakness
dc.subject.keyword Radiological extension
dc.subject.keyword Respiratory muscle function
dc.subject.keyword Upper limb muscle function
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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