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The Menstrual cycle modulates whole-brain turbulent dynamics

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dc.contributor.author De Filippi, Eleonora
dc.contributor.author Uribe, Carme
dc.contributor.author Avila-Varela, Daniela S.
dc.contributor.author Martínez-Molina, Noelia
dc.contributor.author Gashaj, Venera
dc.contributor.author Pritschet, Laura
dc.contributor.author Santander, Tyler
dc.contributor.author Jacobs, Emily G.
dc.contributor.author Kringelbach, Morten L.
dc.contributor.author Sanz Perl, Yonatan
dc.contributor.author Deco, Gustavo
dc.contributor.author Escrichs, Anira
dc.date.accessioned 2022-06-27T06:31:33Z
dc.date.available 2022-06-27T06:31:33Z
dc.date.issued 2021
dc.identifier.citation De Filippi E, Uribe C, Avila-Varela DS, Martínez-Molina N, Gashaj V, Pritschet L, Santander T, Jacobs EG, Kringelbach ML, Sanz Perl Y, Deco G, Escrichs A. The Menstrual cycle modulates whole-brain turbulent dynamics. Front Neurosci. 2021;15:753820. DOI: 10.3389/fnins.2021.753820
dc.identifier.issn 1662-4548
dc.identifier.uri http://hdl.handle.net/10230/53594
dc.description.abstract Brain dynamics have recently been shown to be modulated by rhythmic changes in female sex hormone concentrations across an entire menstrual cycle. However, many questions remain regarding the specific differences in information processing across spacetime between the two main follicular and luteal phases in the menstrual cycle. Using a novel turbulent dynamic framework, we studied whole-brain information processing across spacetime scales (i.e., across long and short distances in the brain) in two open-source, dense-sampled resting-state datasets. A healthy naturally cycling woman in her early twenties was scanned over 30 consecutive days during a naturally occurring menstrual cycle and under a hormonal contraceptive regime. Our results indicated that the luteal phase is characterized by significantly higher information transmission across spatial scales than the follicular phase. Furthermore, we found significant differences in turbulence levels between the two phases in brain regions belonging to the default mode, salience/ventral attention, somatomotor, control, and dorsal attention networks. Finally, we found that changes in estradiol and progesterone concentrations modulate whole-brain turbulent dynamics in long distances. In contrast, we reported no significant differences in information processing measures between the active and placebo phases in the hormonal contraceptive study. Overall, the results demonstrate that the turbulence framework is able to capture differences in whole-brain turbulent dynamics related to ovarian hormones and menstrual cycle stages.
dc.description.sponsorship AE and GD were supported by the HBP SGA3 Human Brain Project Specific Grant Agreement 3 (grant agreement no. 945539), funded by the EU H2020 FET Flagship.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Frontiers in neuroscience. 2021;15:753820.
dc.rights © 2021 De Filippi, Uribe, Avila-Varela, Martínez-Molina, Gashaj, Pritschet, Santander, Jacobs, Kringelbach, Sanz Perl, Deco and Escrichs. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title The Menstrual cycle modulates whole-brain turbulent dynamics
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://doi.org/10.3389/fnins.2021.753820
dc.subject.keyword menstrual cycle
dc.subject.keyword turbulence
dc.subject.keyword brain information processing
dc.subject.keyword whole-brain dynamics
dc.subject.keyword resting-state fMRI
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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