Welcome to the UPF Digital Repository

The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians

Show simple item record

dc.contributor.author Spruce, Thomas
dc.contributor.author Plass Pórtulas, Mireya, 1982-
dc.contributor.author Gohr, André
dc.contributor.author Ray, Debashish
dc.contributor.author Martínez de Lagrán Cabredo, María
dc.contributor.author Rot, Gregor
dc.contributor.author Nóvoa, Ana
dc.contributor.author Burguera, Demián
dc.contributor.author Permanyer, Jon
dc.contributor.author Miret-Cuesta, Marta
dc.contributor.author Zheng, Hong
dc.contributor.author Swanson, Maurice S.
dc.contributor.author Morris, Quaid
dc.contributor.author Mallo, Moises
dc.contributor.author Dierssen, Mara
dc.contributor.author Hughes, Timothy R.
dc.contributor.author Pernaute, Barbara
dc.contributor.author Irimia, Manuel
dc.date.accessioned 2022-06-21T09:18:17Z
dc.date.available 2022-06-21T09:18:17Z
dc.date.issued 2022
dc.identifier.citation Spruce T, Plass M, Gohr A, Ray D, Martínez de Lagrán M, Rot G et al. The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians. PLoS Biol. 2022 Apr 27;20(4):e3001615. DOI:10.1371/journal.pbio.3001615
dc.identifier.issn 1544-9173
dc.identifier.uri http://hdl.handle.net/10230/53555
dc.description.abstract Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a striking process of evolutionary specialization in eutherian mammals resulting in the emergence of a novel placental function for the gene. Mbnl3 belongs to a family of RNA-binding proteins whose members regulate multiple aspects of RNA metabolism. We find that, in eutherians, while both Mbnl3 and its paralog Mbnl2 are strongly expressed in placenta, Mbnl3 expression has been lost from nonplacental tissues in association with the evolution of a novel promoter. Moreover, Mbnl3 has undergone accelerated protein sequence evolution leading to changes in its RNA-binding specificities and cellular localization. While Mbnl2 and Mbnl3 share partially redundant roles in regulating alternative splicing, polyadenylation site usage and, in turn, placenta maturation, Mbnl3 has also acquired novel biological functions. Specifically, Mbnl3 knockout (M3KO) alone results in increased placental growth associated with higher Myc expression. Furthermore, Mbnl3 loss increases fetal resource allocation during limiting conditions, suggesting that location of Mbnl3 on the X chromosome has led to its role in limiting placental growth, favoring the maternal side of the parental genetic conflict.
dc.description.sponsorship The research has been funded by the Spanish Ministerio de Ciencia (BFU2017-89201-P and PID2020-115040GB-I00 to M.I.), the ‘Centro de Excelencia Severo Ochoa 2013-2017’(SEV-2012-0208 to the Centre for Genomic Regulation), and the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n° 608959 to T.S.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.rights © 2022 Thomas Spruce et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Genètica
dc.subject.other Expressió gènica
dc.subject.other Proteïnes
dc.subject.other Placenta
dc.subject.other Biologia del desenvolupament
dc.title The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.3001615
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/608959
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-89201-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


Compliant to Partaking