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Modulation of cortical slow oscillations and complexity across anesthesia levels

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dc.contributor.author Dasilva, Miguel
dc.contributor.author Camassa, Alessandra
dc.contributor.author Navarro-Guzman, Alvaro
dc.contributor.author Pazienti, Antonio
dc.contributor.author Perez-Mendez, Lorena
dc.contributor.author Zamora-López, Gorka
dc.contributor.author Mattia, Maurizio
dc.contributor.author Sanchez-Vives, Maria V.
dc.date.accessioned 2022-06-21T05:56:50Z
dc.date.available 2022-06-21T05:56:50Z
dc.date.issued 2021
dc.identifier.citation Dasilva M, Camassa A, Navarro-Guzman A, Pazienti A, Perez-Mendeza L, Zamora-López G, Mattia M, Sanchez-Vives MV. Modulation of cortical slow oscillations and complexity across anesthesia levels. NeuroImage. 2021;224:117415. DOI: 10.1016/j.neuroimage.2020.117415
dc.identifier.issn 1053-8119
dc.identifier.uri http://hdl.handle.net/10230/53534
dc.description.abstract The ability of different groups of cortical neurons to engage in causal interactions that are at once differentiated and integrated results in complex dynamic patterns. Complexity is low during periods of unconsciousness (deep sleep, anesthesia, unresponsive wakefulness syndrome) in which the brain tends to generate a stereotypical pattern consisting of alternating active and silent periods of neural activity—slow oscillations— and is high during wakefulness. But how is cortical complexity built up? Is it a continuum? An open question is whether cortical complexity can vary within the same brain state. Here we recorded with 32-channel multielectrode arrays from the cortical surface of the mouse and used both spontaneous dynamics (wave propagation entropy and functional complexity) and a perturbational approach (a variation of the perturbation complexity index) to measure complexity at different anesthesia levels. Variations in anesthesia level within the bistable regime of slow oscillations (0.1–1.5 Hz) resulted in a modulation of the slow oscillation frequency. Both perturbational and spontaneous complexity increased with decreasing anesthesia levels, in correlation with the decrease in coherence of the underlying network. Changes in complexity level are related to, but not dependent on, changes in excitability. We conclude that cortical complexity can vary within a single brain state dominated by slow oscillations, building up to the higher complexity associated with consciousness.
dc.description.sponsorship Funded by EU H2020 Research and Innovation Programme, Grant 785907 (HBP SGA2) and 945539 (HBP SGA3) to MVSV and to MM, BFU2017-85048-R (MINECO) and SloW-Dyn FLAGERA-PCIN-2015-162-C02-01 to MVSV. IDIBAPS is supported by CERCA (Generalitat de Catalunya) to MVSV.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof NeuroImage. 2021;224:117415.
dc.rights © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Modulation of cortical slow oscillations and complexity across anesthesia levels
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://doi.org/10.1016/j.neuroimage.2020.117415
dc.subject.keyword Slow waves
dc.subject.keyword PCI
dc.subject.keyword Wave propagation
dc.subject.keyword Emergent activity
dc.subject.keyword Cortical connectivity
dc.subject.keyword Up states
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-85048-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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