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Cognition in recent suicide attempts: altered executive function

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dc.contributor.author Fernández-Sevillano, Jessica
dc.contributor.author Alberich, Susana
dc.contributor.author Zorrilla, Iñaki
dc.contributor.author González-Ortega, I.
dc.contributor.author López, María Purificación
dc.contributor.author Pérez Solá, Victor
dc.contributor.author Vieta, Eduard
dc.contributor.author González-Pinto, Ana
dc.contributor.author Saiz, Pilar A.
dc.date.accessioned 2022-06-09T06:54:04Z
dc.date.available 2022-06-09T06:54:04Z
dc.date.issued 2021
dc.identifier.citation Fernández-Sevillano J, Alberich S, Zorrilla I, González-Ortega I, López MP, Pérez V, et al. Cognition in recent suicide attempts: altered executive function. Front Psychiatry. 2021 Jul 22; 12: 701140. DOI: 10.3389/fpsyt.2021.701140
dc.identifier.issn 1664-0640
dc.identifier.uri http://hdl.handle.net/10230/53427
dc.description.abstract Background: Neuropsychological alterations can lead to inaccurate perception, interpretation, and response to environmental information, which could be a risk factor for suicide. Methods: Ninety-six subjects were recruited from the Psychiatry Department of the Araba University Hospital-Santiago, including 20 patients with a recent attempt and diagnosis of major depressive disorder (MDD) according to DSM-V, 33 MDD patients with history of attempted suicide, 23 non-attempter MDD patients, and 20 healthy controls. All participants underwent a clinical interview and neuropsychological assessment on the following cognitive domains: working memory, processing speed, decision-making, executive function, and attention. Backward multiple regressions were performed adjusting for significant confounding variables. For group comparisons, ANOVA and Bonferroni post-hoc tests were performed with a p < 0.05 significance level. Results: The patient groups did not differ regarding severity of depression and stressful events in the last 6 months. In comparison to healthy controls, depressed patients with lifetime suicide attempts had more general trauma (p = 0.003), emotional abuse (p = 0.003), emotional negligence (p = 0.006), and physical negligence (p = 0.009), and depressed patients with recent suicide attempts had experienced more child sexual abuse (p = 0.038). Regarding neuropsychological assessment, all patient groups performed significantly worse than did healthy controls in processing speed, decision-making, and attention. Comparisons between patient groups indicated that recent suicide attempters had poorer performance on executive function in comparison to both depressed lifetime attempters and depressed non-attempters (B = 0.296, p = 0.019, and B = 0.301, p = 0.028, respectively). Besides, women with recent attempts had slightly better scores on executive function than males. Regarding the rest of the cognitive domains, there were no significant differences between groups. Conclusion: Executive function performance is altered in recent suicide attempts. As impaired executive function can be risk factor for suicide, preventive interventions on suicide should focus on its assessment and rehabilitation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.rights Copyright © 2021 Fernández-Sevillano, Alberich, Zorrilla, González-Ortega, López, Pérez, Vieta, González-Pinto and Saíz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Cognition in recent suicide attempts: altered executive function
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2021.701140
dc.subject.keyword Cognition
dc.subject.keyword Executive function
dc.subject.keyword Major depressive disorders
dc.subject.keyword Suicide
dc.subject.keyword Trauma
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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