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Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study

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dc.contributor.author Pasqual, Elisa, 1989-
dc.contributor.author Turner, Michelle C.
dc.contributor.author Gracia-Lavedan, Esther
dc.contributor.author Casabonne, Delphine
dc.contributor.author Benavente, Yolanda
dc.contributor.author Thierry-Chef, Isabelle
dc.contributor.author Maynadié, Marc
dc.contributor.author Cocco, Pierluigi
dc.contributor.author Staines, Anthony
dc.contributor.author Foretova, Lenka
dc.contributor.author Nieters, Alexandra
dc.contributor.author Boffetta, Paolo
dc.contributor.author Brennan, Paul
dc.contributor.author Cardis, Elisabeth
dc.contributor.author de Sanjosé, Silvia
dc.date.accessioned 2022-05-31T07:00:37Z
dc.date.available 2022-05-31T07:00:37Z
dc.date.issued 2020
dc.identifier.citation Pasqual E, Turner MC, Gracia-Lavedan E, Casabonne D, Benavente Y, Thierry Chef I, Maynadié M, Cocco P, Staines A, Foretova L, Nieters A, Boffetta P, Brennan P, Cardis E, de Sanjose S. Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study. PLoS One. 2020 Jul 10;15(7):e0235658. DOI: 10.1371/journal.pone.0235658
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/53323
dc.description.abstract Medical diagnostic X-rays are an important source of ionizing radiation (IR) exposure in the general population; however, it is unclear if the resulting low patient doses increase lymphoma risk. We examined the association between lifetime medical diagnostic X-ray dose and lymphoma risk, taking into account potential confounding factors, including medical history. The international Epilymph study (conducted in the Czech-Republic, France, Germany, Ireland, Italy, and Spain) collected self-reported information on common diagnostic X-ray procedures from 2,362 lymphoma cases and 2,465 frequency-matched (age, sex, country) controls. Individual lifetime cumulative bone marrow (BM) dose was estimated using time period-based dose estimates for different procedures and body parts. The association between categories of BM dose and lymphoma risk was examined using unconditional logistic regression models adjusting for matching factors, socioeconomic variables, and the presence of underlying medical conditions (atopic, autoimmune, infectious diseases, osteoarthritis, having had a sick childhood, and family history of lymphoma) as potential confounders of the association. Cumulative BM dose was low (median 2.25 mGy) and was not positively associated with lymphoma risk. Odds ratios (ORs) were consistently less than 1.0 in all dose categories compared to the reference category (less than 1 mGy). Results were similar after adjustment for potential confounding factors, when using different exposure scenarios, and in analyses by lymphoma subtype and by type of control (hospital-, population-based). Overall no increased risk of lymphoma was observed. The reduced ORs may be related to unmeasured confounding or other sources of systematic bias.We found little evidence that chronic medical conditions confound lymphoma risk and medical radiation associations.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One. 2020 Jul 10;15(7):e0235658
dc.rights © 2020 Pasqual et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0235658
dc.subject.keyword Lymphoma
dc.subject.keyword Cancer risk factors
dc.subject.keyword Medical risk factors
dc.subject.keyword Oncology
dc.subject.keyword X-ray radiography
dc.subject.keyword Bone marrow
dc.subject.keyword Diagnostic medicine
dc.subject.keyword Cancer detection and diagnosis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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