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Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children

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dc.contributor.author de Prado-Bert, Paula
dc.contributor.author Warembourg, Charline
dc.contributor.author Borràs, Eva
dc.contributor.author Sabidó Aguadé, Eduard, 1981-
dc.contributor.author Urquiza, José M.
dc.contributor.author Maitre, Léa
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author de Castro, Montserrat
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author Vrijheid, Martine
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Bustamante Pineda, Mariona
dc.date.accessioned 2022-05-25T10:14:50Z
dc.date.available 2022-05-25T10:14:50Z
dc.date.issued 2022
dc.identifier.citation de Prado-Bert P, Warembourg C, Dedele A, Heude B, Borràs E, Sabidó E et al. Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children. Environ Res. 2022 Mar 12;211:113109. DOI:10.1016/j.envres.2022.113109
dc.identifier.issn 0013-9351
dc.identifier.uri http://hdl.handle.net/10230/53260
dc.description.abstract Exposure to air pollution influences children's health, however, the biological mechanisms underlying these effects are not completely elucidated. We investigated the association between short- and medium-term outdoor air pollution exposure with protein profiles and their link with blood pressure in 1170 HELIX children aged 6-11 years. Different air pollutants (NO2, PM10, PM2.5, and PM2.5abs) were estimated based on residential and school addresses at three different windows of exposure (1-day, 1-week, and 1-year before clinical and molecular assessment). Thirty-six proteins, including adipokines, cytokines, or apolipoproteins, were measured in children's plasma using Luminex. Systolic and diastolic blood pressure (SBP and DBP) were measured following a standardized protocol. We performed an association study for each air pollutant at each location and time window and each outcome, adjusting for potential confounders. After correcting for multiple-testing, hepatocyte growth factor (HGF) and interleukin 8 (IL8) levels were positively associated with 1-week home exposure to some of the pollutants (NO2, PM10, or PM2.5). NO2 1-week home exposure was also related to higher SBP. The mediation study suggested that HGF could explain 19% of the short-term effect of NO2 on blood pressure, but other study designs are needed to prove the causal directionality between HGF and blood pressure.
dc.description.sponsorship The study received funding from the European Community’s Seventh Framework Programme (FP7/2007–206) (grant agreement no 308333) (HELIX project), the H2020-EU.3.1.2. - Preventing Disease Programme (grant agreement no 874583) (ATHLETE project) and from the European Union’s Horizon 2020 research and innovation programme (grant Agreement number: 733206) (Early Life stressors and Lifecycle Health (LIFECYCLE)). BiB received funding from the Welcome Trust (WT101597MA), from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/ 1). The study was supported by the European Union FP7 programmes (FP7/ 2007–2013, HELIX, ESCAPE, ENRIECO, Medall projects). INMA was supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV. 2007.1.2.2.2. Project No 211250 Escape, EU FP7- 2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV. 2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX). MC received funding from Instituto Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128). JU is supported by Spanish regional program PERIS (Ref.: SLT017/20/ 000119) Granted by Departament de Salut de la Generalitat de Catalunya. The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I + D + i 2013–2016 from the Instituto de Salud Carlos III (ISCIII)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © 2022 Paula de Prado_Bert et al. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Aire -- Contaminació
dc.subject.other Pressió sanguínia
dc.subject.other Infants
dc.subject.other Proteïnes
dc.title Short- and medium-term air pollution exposure, plasmatic protein levels and blood pressure in children
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2022.113109
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226756
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/241604
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/16320
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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