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dc.contributor.author | Espinosa Blay, Lluís |
dc.contributor.other | Marruecos, Laura |
dc.date.accessioned | 2022-05-20T06:49:15Z |
dc.date.available | 2022-05-20T06:49:15Z |
dc.date.issued | 2021 |
dc.identifier.citation | Espinosa L, Marruecos L. NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and càncer. Biomedicines. 2021 Sep 21; 9(9): 1278. DOI: 10.3390/biomedicines9091278 |
dc.identifier.issn | 2227-9059 |
dc.identifier.uri | http://hdl.handle.net/10230/53187 |
dc.description.abstract | IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.rights | Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.title | NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and cancer |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.3390/biomedicines9091278 |
dc.subject.keyword | IκBα |
dc.subject.keyword | NF-κB |
dc.subject.keyword | SUMOylation |
dc.subject.keyword | Cancer |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |