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Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece

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dc.contributor.author Howe, Caitlin G.
dc.contributor.author Margetaki, Katerina
dc.contributor.author Vafeiadi, Marina, 1983-
dc.contributor.author Roumeliotaki, Theano
dc.contributor.author Karachaliou, Marianna
dc.contributor.author Kogevinas, Manolis
dc.contributor.author McConnell, Rob
dc.contributor.author Eckel, Sandrah P.
dc.contributor.author Conti, David V.
dc.contributor.author Kippler, Maria
dc.contributor.author Farzan, Shohreh F.
dc.contributor.author Chatzi, Leda
dc.date.accessioned 2022-05-13T06:35:46Z
dc.date.available 2022-05-13T06:35:46Z
dc.date.issued 2021
dc.identifier.citation Howe CG, Margetaki K, Vafeiadi M, Roumeliotaki T, Karachaliou M, Kogevinas M, McConnell R, Eckel SP, Conti DV, Kippler M, Farzan SF, Chatzi L. Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece. Environ Health. 2021 Jan 6;20(1):1. DOI: 10.1186/s12940-020-00685-9
dc.identifier.issn 1476-069X
dc.identifier.uri http://hdl.handle.net/10230/53074
dc.description.abstract Background: Child blood pressure (BP) is predictive of future cardiovascular risk. Prenatal exposure to metals has been associated with higher BP in childhood, but most studies have evaluated elements individually and measured BP at a single time point. We investigated impacts of prenatal metal mixture exposures on longitudinal changes in BP during childhood and elevated BP at 11 years of age. Methods: The current study included 176 mother-child pairs from the Rhea Study in Heraklion, Greece and focused on eight elements (antimony, arsenic, cadmium, cobalt, lead, magnesium, molybdenum, selenium) measured in maternal urine samples collected during pregnancy (median gestational age at collection: 12 weeks). BP was measured at approximately 4, 6, and 11 years of age. Covariate-adjusted Bayesian Varying Coefficient Kernel Machine Regression and Bayesian Kernel Machine Regression (BKMR) were used to evaluate metal mixture impacts on baseline and longitudinal changes in BP (from ages 4 to 11) and the development of elevated BP at age 11, respectively. BKMR results were compared using static versus percentile-based cutoffs to define elevated BP. Results: Molybdenum and lead were the mixture components most consistently associated with BP. J-shaped relationships were observed between molybdenum and both systolic and diastolic BP at age 4. Similar associations were identified for both molybdenum and lead in relation to elevated BP at age 11. For molybdenum concentrations above the inflection points (~ 40-80 μg/L), positive associations with BP at age 4 were stronger at high levels of lead. Lead was positively associated with BP measures at age 4, but only at high levels of molybdenum. Potential interactions between molybdenum and lead were also identified for BP at age 11, but were sensitive to the cutoffs used to define elevated BP. Conclusions: Prenatal exposure to high levels of molybdenum and lead, particularly in combination, may contribute to higher BP at age 4. These early effects appear to persist throughout childhood, contributing to elevated BP in adolescence. Future studies are needed to identify the major sources of molybdenum and lead in this population.
dc.description.sponsorship This work was supported by NIEHS [grant numbers R21ES029681 (Chatzi, Conti, McConnell), R01ES030691 (Chatzi, Conti, McConnell, Eckel), R01ES029944 (Chatzi, Conti, Margetaki), R01 ES030364 (Chatzi, Conti, McConnell, Eckel), R21ES028903 (Chatzi, McConnell, Eckel), P30ES007048 (Chatzi, Conti, McConnell, Eckel), K99 ES030400 (Howe), R00ES024144 (Farzan), and Horizon 2020 – European Framework Programme for Research and Innovation, ATHLETE, (Chatzi, Conti), P01CA196569, R01CA140561, R01ES016813 (Conti)]. The Rhea project was financially supported by the European Union [grant numbers EU FP6–2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007. Project No 211250 Escape, EU FP7–2008-ENV- Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX) and the Greek Ministry of Health.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Environ Health. 2021 Jan 6;20(1):1
dc.rights © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s12940-020-00685-9
dc.subject.keyword Blood pressure
dc.subject.keyword Childhood
dc.subject.keyword Metals
dc.subject.keyword Mixtures
dc.subject.keyword Prenatal
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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