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Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer

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dc.contributor.author Villanueva, Cristina M.
dc.contributor.author Espinosa Díaz, Ana
dc.contributor.author Gracia-Lavedan, Esther
dc.contributor.author Vlaanderen, Jelle
dc.contributor.author Vermeulen, Roel
dc.contributor.author Molina, Antonio J.
dc.contributor.author Amiano, Pilar
dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Vineis, Paolo
dc.contributor.author Kogevinas, Manolis
dc.date.accessioned 2022-05-05T05:51:06Z
dc.date.available 2022-05-05T05:51:06Z
dc.date.issued 2021
dc.identifier.citation Villanueva CM, Espinosa A, Gracia-Lavedan E, Vlaanderen J, Vermeulen R, Molina AJ, Amiano P, Gómez-Acebo I, Castaño-Vinyals G, Vineis P, Kogevinas M. Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer. Environ Int. 2021 Dec;157:106873. DOI: 10.1016/j.envint.2021.106873
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/52986
dc.description.abstract Background: Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water associated with colorectal cancer risk but mechanisms are not well understood. Objectives: We explored the association between exposure to THMs and nitrate in drinking water and inflammation markers, and the link with colorectal cancer risk. Methods: A subset of 198 colorectal cancer cases and 205 controls from the multicase-control study MCC-Spain were included. Average concentration of THMs (chloroform, bromodichloromethane, dibromochloromethane, bromoform) and nitrate in tap water at the residence was estimated from age 18 until 2 years before the interview ("long term") and for a recent period (3 years before diagnosis). Serum levels of EGF, eotaxin, G-CSF, IL-17E, IL-1rA, IL-8, IP-10, MDC, MPO, periostin, VEGF, and C-reactive protein (CRP) were measured. We estimated the linear association between inflammation markers and exposure among controls, and the odds ratio of colorectal cancer associated with THM and nitrate exposure, and inflammation markers. A mediation analysis was conducted to identify inflammation markers in the pathway between THM/nitrate exposure and colorectal cancer. Results: Serum concentrations of EGF, IL-8, IL-17E and eotaxin increased with recent residential levels of brominated THMs, chloroforom and/or total THM. No associations were observed for nitrate and for long-term residential THM levels. All residential exposures except chloroform were positively associated with colorectal cancer. Serum concentrations of VEGF and periostin were positively associated with colorectal cancer, while EGF was inversely associated. One protein-exposure combination (periostin-recent ingested brominated THMs) slightly mediated the association with colorectal cancer risk. Discussion: Results suggest that estimated THM exposure is involved in inflammation processes. However, the study design was limited to stablish etiologically relevant associations between the protein levels and colorectal cancer risk. The lack of association between nitrate exposure and inflammation markers suggests other biological mechanisms are involved in the link with colorectal cancer.
dc.description.sponsorship We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. This work was funded by the 7th Framework Programme EXPOSOMICS Project (grant agreement 308610), the Acción Transversal del Cáncer del Consejo de Ministros del 11/10/2007, and the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI11/00226) FIS grants.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Int. 2021 Dec;157:106873
dc.rights © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2021.106873
dc.subject.keyword Colorectal cancer
dc.subject.keyword Drinking water
dc.subject.keyword Immune response
dc.subject.keyword Inflammation
dc.subject.keyword Nitrate
dc.subject.keyword Trihalomethanes
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308610
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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