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Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors

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dc.contributor.author Lozano, Manuel
dc.contributor.author Murcia, Mario
dc.contributor.author Soler Blasco, Raquel
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Zubero, Begotxu
dc.contributor.author Riutort-Mayol, Gabriel
dc.contributor.author Gil, Fernando
dc.contributor.author Olmedo, Pablo
dc.contributor.author Grimalt Obrador, Joan
dc.contributor.author Amorós, Rubén
dc.contributor.author Lertxundi, Aitana
dc.contributor.author Vrijheid, Martine
dc.contributor.author Ballester Díez, Ferran
dc.contributor.author Llop, Sabrina
dc.date.accessioned 2022-04-29T06:43:51Z
dc.date.available 2022-04-29T06:43:51Z
dc.date.issued 2022
dc.identifier.citation Lozano M, Murcia M, Soler-Blasco R, Casas M, Zubero B, Riutort-Mayol G, Gil F, Olmedo P, Grimalt JO, Amorós R, Lertxundi A, Vrijheid M, Ballester F, Llop S. Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors. Chemosphere. 2022 Jan;286(Pt 2):131809. DOI: 10.1016/j.chemosphere.2021.131809
dc.identifier.issn 0045-6535
dc.identifier.uri http://hdl.handle.net/10230/52940
dc.description.abstract Background: Humans are regularly exposed to metals and metalloids present in air, water, food, soil and domestic materials. Most of them can cross the placental barrier and cause adverse impacts on the developing foetus. Objectives: To describe the prenatal concentrations of metals and metalloids and to study the associated sociodemographic, environmental and dietary factors in pregnant Spanish women. Methods: Subjects were 1346 pregnant women of the INMA Project, for whom the following metals arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl) and zinc (Zn) were determined in urine, at both the first and the third trimesters of gestation. Sociodemographic, dietary and environmental information was collected through questionnaires during pregnancy. Multiple linear mixed models were built in order to study the association between each metal and metalloid concentrations and the sociodemographic, environmental and dietary factors. Results: The most detected compounds were As, Co, Mo, Sb, Se and Zn at both trimesters. Zn was the element found in the highest concentrations at both trimesters and Tl was detected in the lowest concentrations. We observed significant associations between As, Cd, Cu, Sb, Tl and Zn concentrations and working situation, social class and age. Seafood, meat, fruits, nuts, vegetables and alcohol intake affected the levels of all the metals but Cd and Cu. Proximity to industrial areas, fields and air pollution were related to all metals except Cd, Sb and Se. Conclusions: This is the first large prospective longitudinal study on the exposure to metals and metalloids during pregnancy and associated factors to include several cohorts in Spain. The present study shows that some modifiable lifestyles, food intakes and environmental factors could be associated with prenatal exposure to metal(loid)s, which may be considered in further studies to assess their relationship with neonatal health outcomes.
dc.description.sponsorship This study was funded by Grants from EU (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5–1); Spain: ISCIII (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/00090, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02187, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI18/01142 and PI19/1338; Miguel Servet FEDER MS15/00025, MS20/0006, CPII16/00051, and FIS-FSE: 17/ 00260); CIBERESP; Generalitat Valenciana: FISABIO (UGP 15–230, UGP-15-244, and UGP-15-249), AICO/2020/285, and Alicia Koplowitz Foundation 2017; Generalitat de Catalunya-CIRIT 1999SGR 00241; Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065); Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Chemosphere. 2022 Jan;286(Pt 2):131809
dc.rights © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.chemosphere.2021.131809
dc.subject.keyword Diet
dc.subject.keyword Environmental exposure
dc.subject.keyword Metalloids
dc.subject.keyword Metals
dc.subject.keyword Prenatal exposure
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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