Welcome to the UPF Digital Repository

Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies

Show simple item record

dc.contributor.author Massó Rodriguez, Anna
dc.contributor.author Hogg, Bridget
dc.contributor.author Gardoki-Souto, Itxaso
dc.contributor.author Valiente Gómez, Alicia
dc.contributor.author Trabsa, Amira
dc.contributor.author Mosquera, Dolores
dc.contributor.author García-Estela, Aitana
dc.contributor.author Colom, Francesc
dc.contributor.author Pérez, Victor
dc.contributor.author Padberg, Frank
dc.contributor.author Moreno Alcázar, Ana
dc.contributor.author Amann, Benedikt Lorenz
dc.date.accessioned 2022-02-23T07:32:26Z
dc.date.available 2022-02-23T07:32:26Z
dc.date.issued 2021
dc.identifier.citation Massó Rodriguez A, Hogg B, Gardoki-Souto I, Valiente-Gómez A, Trabsa A, Mosquera D, García-Estela A, Colom F, Pérez V, Padberg F, Moreno-Alcázar A, Amann BL. Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies. Front Psychiatry. 2021 Jun 9;12:681876. DOI: 10.3389/fpsyt.2021.681876
dc.identifier.issn 1664-0640
dc.identifier.uri http://hdl.handle.net/10230/52544
dc.description.abstract Background: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiology. Objective: The objective of this review is to summarize evidence regarding clinical features, neuropsychological performance and neuroimaging findings from cross-diagnostic studies comparing BD and BPD, to further caracterize their complex interplay. Methods: Using PubMed, PsycINFO and TripDataBase, we conducted a systematic literature search based on PRISMA guidelines of studies published from January 1980 to September 2019 which directly compared BD and BPD. Results: A total of 28 studies comparing BD and BPD were included: 19 compared clinical features, 6 neuropsychological performance and three neuroimaging abnormalities. Depressive symptoms have an earlier onset in BPD than BD. BD patients present more mixed or manic symptoms, with BD-I differing from BPD in manic phases. BPD patients show more negative attitudes toward others and self, more conflictive interpersonal relationships, and more maladaptive regulation strategies in affective instability with separate pathways. Impulsivity seems more a trait in BPD rather than a state as in BD. Otherwise, BD and BPD overlap in depressive and anxious symptoms, dysphoria, various abnormal temperamental traits, suicidal ideation, and childhood trauma. Both disorders differ and share deficits in neuropsychological and neuroimaging findings. Conclusion: Clinical data provide evidence of overlapping features in both disorders, with most of those shared symptoms being more persistent and intense in BPD. Thus, categorical classifications should be compared to dimensional approaches in transdiagnostic studies investigating BPD features in BD regarding their respective explanatory power for individual trajectories. Systematic Review Registration: The search strategy was pre-registered in PROSPERO: CRD42018100268.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Front Psychiatry. 2021 Jun 9;12:681876
dc.rights © 2021 Massó Rodriguez, Hogg, Gardoki-Souto, Valiente-Gómez, Trabsa, Mosquera, García-Estela, Colom, Pérez, Padberg, Moreno-Alcázar and Amann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Clinical features, neuropsychology and neuroimaging in bipolar and borderline personality disorder: a systematic review of cross-diagnostic studies
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2021.681876
dc.subject.keyword Affective continuum
dc.subject.keyword Bipolar disorder
dc.subject.keyword Borderline personality disorder
dc.subject.keyword Clinical features
dc.subject.keyword Cognitive functions
dc.subject.keyword Neuroimaging
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


In collaboration with Compliant to Partaking