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Role of cannabinoids in alcohol-induced neuroinflammation

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dc.contributor.author García Baos, Alba
dc.contributor.author Alegre Zurano, Laia
dc.contributor.author Cantacorps Centellas, Lídia, 1991-
dc.contributor.author Martín Sánchez, Ana
dc.contributor.author Valverde Granados, Olga
dc.date.accessioned 2022-01-28T08:06:03Z
dc.date.available 2022-01-28T08:06:03Z
dc.date.issued 2021
dc.identifier.citation García-Baos A, Alegre-Zurano L, Cantacorps L, Martín-Sánchez A, Valverde O. Role of cannabinoids in alcohol-induced neuroinflammation. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110054. DOI: 10.1016/j.pnpbp.2020.110054
dc.identifier.issn 0278-5846
dc.identifier.uri http://hdl.handle.net/10230/52355
dc.description.abstract Alcohol is a psychoactive substance highly used worldwide, whose harmful use might cause a broad range of mental and behavioural disorders. Underlying brain impact, the neuroinflammatory response induced by alcohol is recognised as a key contributing factor in the progression of other neuropathological processes, such as neurodegeneration. These sequels are determined by multiple factors, including age of exposure. Strikingly, it seems that the endocannabinoid system modulation could regulate the alcohol-induced neuroinflammation. Although direct CB1 activation can worsen alcohol consequences, targeting other components of the expanded endocannabinoid system may counterbalance the pro-inflammatory response. Indeed, specific modulations of the expanded endocannabinoid system have been proved to exert anti-inflammatory effects, primarily through the CB2 and PPARγ signalling. Among them, some endo- and exogeneous cannabinoids can block certain pro-inflammatory mediators, such as NF-κB, thereby neutralizing the neuroinflammatory intracellular cascades. Furthermore, a number of cannabinoids are able to activate complementary anti-inflammatory pathways, which are necessary for the transition from chronically overactivated microglia to a regenerative microglial phenotype. Thus, cannabinoid modulation provides cooperative anti-inflammatory mechanisms that may be advantageous to resolve a pathological neuroinflammation in an alcohol-dependent context.
dc.description.sponsorship This study was funded by Ministerio de Economia y Competitividad (grant number SAF2016-75966-R-FEDER), Ministerio de Sanidad (Retic-ISCIII, RD16/017/010 and Plan Nacional sobre Drogas2018/007). This study was funded by FI-AGAUR (grant number 2019FI_B 0008) and by Ministerio de Economía and Competitividad (FPI, grant number BES-2017-080066). The Department of Experimental and Health Sciences (UPF) is an “Unidad de Excelencia María de Maeztu” funded by the MINECO (Ref. MDM-2014-0370).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 10;104:110054
dc.rights © Elsevier http://dx.doi.org/10.1016/j.pnpbp.2020.110054
dc.title Role of cannabinoids in alcohol-induced neuroinflammation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.pnpbp.2020.110054
dc.subject.keyword Alcohol
dc.subject.keyword Cannabinoids
dc.subject.keyword Neuroinflammation
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75966-R-FEDER
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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