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Ancient and modern mitogenomes from Central Argentina: new insights into population continuity, temporal depth and migration in South America

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dc.contributor.author García, Angelina
dc.contributor.author Nores, Rodrigo
dc.contributor.author Motti, Josefina M. B.
dc.contributor.author Pauro, Maia
dc.contributor.author Luisi, Pierre, 1985-
dc.contributor.author Bravi, Claudio M.
dc.contributor.author Fabra, Mariana
dc.contributor.author Gosling, Anna
dc.contributor.author Kardailsky, Olga
dc.contributor.author Boocock, James
dc.contributor.author Solé Morata, Neus, 1988-
dc.contributor.author Matisoo Smith, Elizabeth
dc.contributor.author Comas, David, 1969-
dc.contributor.author Demarchi, Darío A.
dc.date.accessioned 2022-01-24T07:43:19Z
dc.date.issued 2021
dc.identifier.citation García A, Nores R, Motti JMB, Pauro M, Luisi P, Bravi CM, Fabra M, Gosling AL, Kardailsky O, Boocock J, Solé-Morata N, Matisoo-Smith EA, Comas D, Demarchi DA. Ancient and modern mitogenomes from Central Argentina: new insights into population continuity, temporal depth and migration in South America. Hum Mol Genet. 2021;30(13):1200-17. DOI: 10.1093/hmg/ddab105
dc.identifier.issn 0964-6906
dc.identifier.uri http://hdl.handle.net/10230/52293
dc.description.abstract The inverted triangle shape of South America places Argentina territory as a geographical crossroads between the two principal peopling streams that followed either the Pacific or the Atlantic coasts, which could have then merged in Central Argentina (CA). Although the genetic diversity from this region is therefore crucial to decipher past population movements in South America, its characterization has been overlooked so far. We report 92 modern and 22 ancient mitogenomes spanning a temporal range of 5000 years, which were compared with a large set of previously reported data. Leveraging this dataset representative of the mitochondrial diversity of the subcontinent, we investigate the maternal history of CA populations within a wider geographical context. We describe a large number of novel clades within the mitochondrial DNA tree, thus providing new phylogenetic interpretations for South America. We also identify several local clades of great temporal depth with continuity until the present time, which stem directly from the founder haplotypes, suggesting that they originated in the region and expanded from there. Moreover, the presence of lineages characteristic of other South American regions reveals the existence of gene flow to CA. Finally, we report some lineages with discontinuous distribution across the Americas, which suggest the persistence of relic lineages likely linked to the first population arrivals. The present study represents to date the most exhaustive attempt to elaborate a Native American genetic map from modern and ancient complete mitochondrial genomes in Argentina and provides relevant information about the general process of settlement in South America.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Hum Mol Genet. 2021;30(13):1200-17
dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in Human molecular genetics following peer review. The version of record García A, Nores R, Motti JMB, Pauro M, Luisi P, Bravi CM, Fabra M, Gosling AL, Kardailsky O, Boocock J, Solé-Morata N, Matisoo-Smith EA, Comas D, Demarchi DA. Ancient and modern mitogenomes from Central Argentina: new insights into population continuity, temporal depth and migration in South America. Hum Mol Genet. 2021;30(13):1200-17. DOI: 10.1093/hmg/ddab105 is available online at: http://dx.doi.org/10.1093/hmg/ddab105
dc.title Ancient and modern mitogenomes from Central Argentina: new insights into population continuity, temporal depth and migration in South America
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/hmg/ddab105
dc.subject.keyword Mitochondria
dc.subject.keyword Americas
dc.subject.keyword Argentina
dc.subject.keyword Demography
dc.subject.keyword DNA
dc.subject.keyword Mitochondrial
dc.subject.keyword Genes
dc.subject.keyword Genome
dc.subject.keyword Haplotypes
dc.subject.keyword Mothers
dc.subject.keyword South america
dc.subject.keyword Trees (plant)
dc.subject.keyword Genetics
dc.subject.keyword Native
dc.subject.keyword Americans
dc.subject.keyword Fluid flow
dc.subject.keyword Datasets
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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