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Association between polyphenol intake and gastric cancer risk by anatomic and histologic subtypes: MCC-Spain

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dc.contributor.author Rubín-García, María
dc.contributor.author Vitelli Storelli, Facundo
dc.contributor.author Molina, Antonio J.
dc.contributor.author Zamora-Ros, Raúl
dc.contributor.author Aragonés, Núria
dc.contributor.author Ardanaz Aicua, Eva
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Obón-Santacana Mireia
dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Molina-Barceló, Ana
dc.contributor.author Fernández-Tardón, Guillermo
dc.contributor.author Jiménez-Moleón, José Juan
dc.contributor.author Alguacil Ojeda, Juan
dc.contributor.author Chirlaque, María Dolores
dc.contributor.author Toledo, Estefania
dc.contributor.author Pérez-Gómez, Beatriz
dc.contributor.author Pollan, Marina
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Martín, Vicente
dc.date.accessioned 2022-01-21T07:35:53Z
dc.date.available 2022-01-21T07:35:53Z
dc.date.issued 2020
dc.identifier.citation Rubín-García M, Vitelli-Storelli F, Molina AJ, Zamora-Ros R, Aragonés N, Adarnaz E, et al. Association between polyphenol intake and gastric cancer risk by anatomic and histologic subtypes: MCC-Spain. Nutrients. 2020 Oct 26; 12(11): 3281. DOI: 10.3390/nu12113281
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/52275
dc.description.abstract Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Association between polyphenol intake and gastric cancer risk by anatomic and histologic subtypes: MCC-Spain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu12113281
dc.subject.keyword MCC-Spain
dc.subject.keyword Anatomic
dc.subject.keyword Diet
dc.subject.keyword Epidemiology
dc.subject.keyword Gastric cancer
dc.subject.keyword Histologic
dc.subject.keyword Lignans
dc.subject.keyword Phenolic acids
dc.subject.keyword Polyphenols
dc.subject.keyword Stilbenes
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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