This PhD thesis explores the potential embedded in living organisms, understood as highly complex machines which can sense, compute, and react to changes in their surroundings. From this general idea, we have made use of ...
The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...
Metastasis is the major cause of death from Breast Cancer (BCa). During its progression,
divergent opinions have arisen regarding the hormonal status of the BCa subtypes.
The mammary gland is composed of different cell ...
Microexons are an unusual form of alternative splicing with high evolutionary conservation, however, their functions are still far from being understood. In this thesis, we focused on a neuronal-specific microexon that ...
La regeneración del músculo esquelético depende de la expansión correcta de las células madre inactivas residentes (células satélite), un proceso que se vuelve menos eficiente con el envejecimiento, por razones en gran ...
Gràcies als amplis esforços d'investigació, la nostra comprensió dels mecanismes fisiològics de l'envelliment ha progressat enormement. Recentment, les tecnologies òmiques han permès l'estudi a tot el genoma dels canvis ...
Cognition is a physiological brain function that refers to the process of acquiring and managing knowledge and understanding. It embraces multiple domains, including memory. Intellectual disability disorders such as fragile ...
The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory
decisions regarding chemical safety. The general objective of this thesis is to identify gaps in state-of-the-
art ...
Polycomb repressive complex (PRC) 2 is one of the key regulators of the
transcriptional programs, it maintains stem cell properties and guides cell lineage
specification. It is a multiprotein complex formed by a core and ...
Serradell Noguera, Jose Miguel(Universitat Pompeu Fabra, 2024-04-03)
Since the first peopling of the region, multiple demographic events have occurred generating a complex genetic landscape in North Africa characterized by high genetic heterogeneity and constant gene flow from surrounding ...
The pathologic role of senescent cells is well established in a variety of diseases. Despite the ample evidence that mitochondria play a central role in cellular senescence, the understanding of the adaptations in the ...
El soporte respiratorio no invasivo (SRNI) es utilizado ampliamente en los Servicios de Medicina Intensiva para el tratamiento de la Insuficiencia Respiratoria Aguda Hipoxémica (IRAH). A pesar de los múltiples estudios ...
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...
The general aim of this doctoral thesis was to examine the impact on persons with persistent asthma of inhaled treatment use and sociodemographic factors, in terms of patient-reported outcomes. To achieve this, a new ...
This dissertation examines the transimperial intellectual exchanges between Britons from Hong Kong and Singapore and Filipinos during the Revolution of 1896-1902. It reveals that British newspapermen supported the Filipino ...
Polycomb repressive complex (PRC)1 and 2 are major players in gene regulation, devoted to maintenance of the epigenetic memory of gene silencing. Mouse embryonic stem cells (mESCs) have been extensively exploited as a model ...
El presente estudio parte de una premisa relacionada tanto con intereses investigadores como con una voluntad de aplicación práctica. Tras la identificación de un vacío en la literatura científica referido a la investigación ...
This thesis is about development and its study from a theoretical point of view, with special interest in how to describe development as a dynamical systems' problem. The thesis digs into four directions embedded in this ...
DNA methylation is really important because it is altered due to genetic and environmental factors, and it is associated with common diseases. In this thesis, we identified new factors altering DNA methylation, including ...
Environmental noise pollution has become a major public health concern due to its increase during the last decades as a result of urbanization processes. Environmental noise can be produced by different sources but the ...