Esta Tesis Doctoral presenta la edición y el estudio global de seis certificados de peregrinación a los lugares santos de La Meca y Medina, datados entre los ss. XV y XVI. La particularidad de esta tipología documental ...
García de Castro García, Gonzalo(Universitat Pompeu Fabra, 2024-04-12)
Bilingual infants acquire words at a similar rate as monolingual ones, despite navigating a more
intricate linguistic environment. The mechanisms behind this phenomenon remain elusive. Our
project addressed the potential ...
RNA is a molecule that is released by the different tissues into the
circulation. When it is found in the circulation it is called cell-free
RNA (cfRNA). This type of molecule has great potential as a
noninvasive biomarker ...
Alternative splicing is a post-transcriptional process that allows the generation of
multiple transcript and protein isoforms from a single gene by differential processing
of exons and introns. This Thesis focuses on ...
Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting the formation of ...
Methods for genome engineering have enabled construction of synthetic genomes,
therapeutically reprogrammed cells, synthetic organs, and modification of human genomes.
Design and discovery of genome editors has enabled ...
Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se
originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones
driver que afectan a la vía JAK/STAT. ...
Özer, Ege Ekin(Universitat Pompeu Fabra, 2024-04-12)
In this thesis, we explored neural entrainment as a potential mechanism to underline the
behavioral evidence that certain phonological properties of listeners’ native language affects
speech segmentation. In two experimental ...
This dissertation sheds light on the impact of emotions on consumer behavior within
culinary contexts. Comprising three chapters, the research presents a holistic
exploration through lab experiments and field studies. ...
La metàstasis és responsable del 90% de les morts per càncer, demostrant l’existent manca de coneixement en relació als seus mecanismes moleculars.
Investigacions anteriors del nostre laboratori han demostrat la importància ...
This PhD thesis explores the potential embedded in living organisms, understood as highly complex machines which can sense, compute, and react to changes in their surroundings. From this general idea, we have made use of ...
The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...
Metastasis is the major cause of death from Breast Cancer (BCa). During its progression,
divergent opinions have arisen regarding the hormonal status of the BCa subtypes.
The mammary gland is composed of different cell ...
Microexons are an unusual form of alternative splicing with high evolutionary conservation, however, their functions are still far from being understood. In this thesis, we focused on a neuronal-specific microexon that ...
La regeneración del músculo esquelético depende de la expansión correcta de las células madre inactivas residentes (células satélite), un proceso que se vuelve menos eficiente con el envejecimiento, por razones en gran ...
Gràcies als amplis esforços d'investigació, la nostra comprensió dels mecanismes fisiològics de l'envelliment ha progressat enormement. Recentment, les tecnologies òmiques han permès l'estudi a tot el genoma dels canvis ...
Cognition is a physiological brain function that refers to the process of acquiring and managing knowledge and understanding. It embraces multiple domains, including memory. Intellectual disability disorders such as fragile ...
The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory
decisions regarding chemical safety. The general objective of this thesis is to identify gaps in state-of-the-
art ...
Polycomb repressive complex (PRC) 2 is one of the key regulators of the
transcriptional programs, it maintains stem cell properties and guides cell lineage
specification. It is a multiprotein complex formed by a core and ...
Serradell Noguera, Jose Miguel(Universitat Pompeu Fabra, 2024-04-03)
Since the first peopling of the region, multiple demographic events have occurred generating a complex genetic landscape in North Africa characterized by high genetic heterogeneity and constant gene flow from surrounding ...