• La materialización de la fe islámica: Estudio material, textual e iconográfico de seis certificados de peregrinación a La Meca y Medina (ss. XV-XVI)

  Carro Martín, Sergio (Universitat Pompeu Fabra, 2020-11-18)

  Esta Tesis Doctoral presenta la edición y el estudio global de seis certificados de peregrinación a los lugares santos de La Meca y Medina, datados entre los ss. XV y XVI. La particularidad de esta tipología documental ...
• Bilingual insights into the initial lexicon: the role of cognates in word acquisition

  García de Castro García, Gonzalo (Universitat Pompeu Fabra, 2024-04-12)

  Bilingual infants acquire words at a similar rate as monolingual ones, despite navigating a more intricate linguistic environment. The mechanisms behind this phenomenon remain elusive. Our project addressed the potential ...
• Analysis of circulating RNAs for the early detection of complex diseases using liquid biopsy

  Cabús Fornas, Lluc (Universitat Pompeu Fabra, 2024-04-12)

  RNA is a molecule that is released by the different tissues into the circulation. When it is found in the circulation it is called cell-free RNA (cfRNA). This type of molecule has great potential as a noninvasive biomarker ...
• SRRM3 regulates a subprogram of highly sensitive microexons important for pancreatic endocrine function

  Bajew, Simon (2022-04-25)

  Alternative splicing is a post-transcriptional process that allows the generation of multiple transcript and protein isoforms from a single gene by differential processing of exons and introns. This Thesis focuses on ...
• Dissecting γTuRC recruitment and microtubule nucleation at MTOCs

  Vineethakumari Muraleedharan, Chithran (Universitat Pompeu Fabra, 2024-04-12)

  Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting the formation of ...
• Precise writing of human genomes: engineering & characterizing genome editors for programmable DNA integration in human cells

  Ivancic, Dimitrie (Universitat Pompeu Fabra, 2024-04-12)

  Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome editors has enabled ...
• Dinámica clonal en las neoplasias mieloproliferativas crónicas

  Fernández Ibarrondo, Lierni (Universitat Pompeu Fabra, 2024-04-12)

  Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones driver que afectan a la vía JAK/STAT. ...
• Neural entrainment to languages of different rhythms in adults and infants

  Özer, Ege Ekin (Universitat Pompeu Fabra, 2024-04-12)

  In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. In two experimental ...
• Essays on Emotions and Consumer Behavior in Culinary Contexts

  Kaya, Sandra (Universitat Pompeu Fabra, 2024-01-30)

  This dissertation sheds light on the impact of emotions on consumer behavior within culinary contexts. Comprising three chapters, the research presents a holistic exploration through lab experiments and field studies. ...
• Dietary palmitic acid estabishes an epigenetic memory that promotes metastasis: Implications of neural-related processes in enhacing dissemination

  Domínguez Rodríguez, Diana (Universitat Pompeu Fabra, 2024-04-10)

  La metàstasis és responsable del 90% de les morts per càncer, demostrant l’existent manca de coneixement en relació als seus mecanismes moleculars. Investigacions anteriors del nostre laboratori han demostrat la importància ...
• Genetically engineering living systems: From complex computational scenarios to multiple market applications

  Mogas Diez, Sira (Universitat Pompeu Fabra, 2024-04-09)

  This PhD thesis explores the potential embedded in living organisms, understood as highly complex machines which can sense, compute, and react to changes in their surroundings. From this general idea, we have made use of ...
• A physician-in-the-loop approach by means of machine learning for the diagnosis of lymphocytosis in the clinical laboratory

  Bigorra López, Laura (2022-05-16)

  The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...
• Unraveling luminal breast cancer heterogeneity

  Figueras Puig, Cristina (2022-04-27)

  Metastasis is the major cause of death from Breast Cancer (BCa). During its progression, divergent opinions have arisen regarding the hormonal status of the BCa subtypes. The mammary gland is composed of different cell ...
• Unravelling the roles of an alternatively spliced microexon in Daam1 in nervous system development and function

  Poliński, Patrik (2022-04-22)

  Microexons are an unusual form of alternative splicing with high evolutionary conservation, however, their functions are still far from being understood. In this thesis, we focused on a neuronal-specific microexon that ...
• Maintaining regenerative competence of muscle stem cells: role of mitochondrial dynamics

  Hong, Xiaotong (Universitat Pompeu Fabra, 2022-10-25)

  La regeneración del músculo esquelético depende de la expansión correcta de las células madre inactivas residentes (células satélite), un proceso que se vuelve menos eficiente con el envejecimiento, por razones en gran ...
• Inter-individual variability and temporal scaling in the aging transcriptome

  Martin, Olivier M. F. (2022-04-25)

  Gràcies als amplis esforços d'investigació, la nostra comprensió dels mecanismes fisiològics de l'envelliment ha progressat enormement. Recentment, les tecnologies òmiques han permès l'estudi a tot el genoma dels canvis ...
• Cognitive and synaptic outcomes of targeting peripheral cannabinoid type-1 receptor: focus on naïve and intellectual disability mouse models

  Bergadà Martínez, Araceli (Universitat Pompeu Fabra, 2024-04-03)

  Cognition is a physiological brain function that refers to the process of acquiring and managing knowledge and understanding. It embraces multiple domains, including memory. Intellectual disability disorders such as fragile ...
• Uncertainty analysis of individual predictions and integrated safety assessments in toxicology

  Kopańska, Karolina (Universitat Pompeu Fabra, 2024-04-03)

  The growing importance of uncertainty analysis in toxicology stems from its role in supporting regulatory decisions regarding chemical safety. The general objective of this thesis is to identify gaps in state-of-the- art ...
• Role of polycomb-like proteins in mouse embryonic stem cell differentiation

  Condemi, Livia (Universitat Pompeu Fabra, 2024-04-03)

  Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and ...
• Demographic inference in complex populations: the North African case

  Serradell Noguera, Jose Miguel (Universitat Pompeu Fabra, 2024-04-03)

  Since the first peopling of the region, multiple demographic events have occurred generating a complex genetic landscape in North Africa characterized by high genetic heterogeneity and constant gene flow from surrounding ...

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