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The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells

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dc.contributor.author Giménez Arnau, Anna Maria
dc.contributor.author DeMontojoye, Laurence
dc.contributor.author Asero, Riccardo
dc.contributor.author Cugno, Massimo
dc.contributor.author Kulthanan, Kanokvalai
dc.contributor.author Yanase, Yuhki
dc.contributor.author Hide, Michihiro
dc.contributor.author Kaplan, Allen P.
dc.date.accessioned 2021-11-29T07:33:30Z
dc.date.issued 2021
dc.identifier.citation Giménez-Arnau AM, DeMontojoye L, Asero R, Cugno M, Kulthanan K, Yanase Y, Hide M, Kaplan AP. The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells. J Allergy Clin Immunol Pract. 2021;9(6):2195-208. DOI: 10.1016/j.jaip.2021.03.033
dc.identifier.issn 2213-2198
dc.identifier.uri http://hdl.handle.net/10230/49080
dc.description.abstract Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular infiltrate around small venules of the skin. It consists primarily of CD4(+) lymphocytes, a prominence of the T helper (Th)2 subtype but also Th1 cells, with Th17 cell-derived cytokines elevated in plasma. There are also neutrophils, eosinophils, basophils, and monocytes. Chemokines derived from mast cells and activated endothelial cells drive the process. Although the role of the cellular infiltrate has not previously been addressed, each constituent can contribute to the overall pathogenesis. It is of interest that CSU responds to corticosteroid, yet, short-term steroids do not affect autoimmunity or degranulation of mast cells, and act on margination of cells along the endothelium and chemotaxis to enter the surrounding dermis. In this review, we address each cell's contribution to the overall inflammatory response, as it is currently understood, with a view toward development of therapeutic options that impede the function of critical cells and/or their secretory products.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof J Allergy Clin Immunol Pract. 2021;9(6):2195-208
dc.rights © Elsevier http://dx.doi.org/10.1016/j.jaip.2021.03.033
dc.title The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jaip.2021.03.033
dc.subject.keyword Basophil
dc.subject.keyword Endothelial cell
dc.subject.keyword Eosinophil
dc.subject.keyword Lymphocyte
dc.subject.keyword Neuroinflammation
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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