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Evolution of cytokine production capacity in ancient and modern European populations

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dc.contributor.author Domínguez-Andrés, Jorge
dc.contributor.author Kuijpers, Yunus
dc.contributor.author Bakker, Olivier B.
dc.contributor.author Jaeger, Martin
dc.contributor.author Xu, Cheng-Jian
dc.contributor.author van der Meer, Jos W.M.
dc.contributor.author Jakobsson, Mattias
dc.contributor.author Bertranpetit, Jaume, 1952-
dc.contributor.author Joosten, Leo Ab
dc.contributor.author Li, Yang
dc.contributor.author Netea, Mihai G
dc.date.accessioned 2021-11-10T07:49:00Z
dc.date.available 2021-11-10T07:49:00Z
dc.date.issued 2021
dc.identifier.citation Domínguez-Andrés J, Kuijpers Y, Bakker OB, Jaeger M, Xu CJ, Van der Meer JW, Jakobsson M, Bertranpetit J, Joosten LA, Li Y, Netea MG. Evolution of cytokine production capacity in ancient and modern European populations. Elife. 2021;10:e64971. DOI: 10.7554/eLife.64971
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/48941
dc.description.abstract As our ancestors migrated throughout different continents, natural selection increased the presence of alleles advantageous in the new environments. Heritable variations that alter the susceptibility to diseases vary with the historical period, the virulence of the infections, and their geographical spread. In this study we built polygenic scores for heritable traits that influence the genetic adaptation in the production of cytokines and immune-mediated disorders, including infectious, inflammatory, and autoimmune diseases, and applied them to the genomes of several ancient European populations. We observed that the advent of the Neolithic was a turning point for immune-mediated traits in Europeans, favoring those alleles linked with the development of tolerance against intracellular pathogens and promoting inflammatory responses against extracellular microbes. These evolutionary patterns are also associated with an increased presence of traits related to inflammatory and auto-immune diseases.
dc.description.sponsorship MGN was supported by an ERC Advanced Grant (833247) and a Spinoza Grant of the Netherlands Organization for Scientific Research. YL was supported by an ERC Starting Grant (948207) and the Radboud University Medical Centre Hypatia Grant (2018) for Scientific Research. JD-A is supported by The Netherlands Organization for Scientific Research (VENI grant 09150161910024). JB was supported by PID2019-110933GB-I00 (AEI/FEDER, UE) MINECO, Spain.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof Elife. 2021;10:e64971
dc.rights © 2021, Domínguez-Andrés et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Evolution of cytokine production capacity in ancient and modern European populations
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.64971
dc.subject.keyword Adaptation
dc.subject.keyword Disease
dc.subject.keyword Evolution
dc.subject.keyword Genetics
dc.subject.keyword Genomics
dc.subject.keyword Human
dc.subject.keyword Immune system
dc.subject.keyword Immunology
dc.subject.keyword Inflammation
dc.subject.keyword Neolithic
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/833247
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/948207
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110933GB-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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