Welcome to the UPF Digital Repository

A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure

Show simple item record

dc.contributor.author Poyatos, Lourdes
dc.contributor.author Papaseit Fontanet, Esther
dc.contributor.author Olesti Muñoz, Eulàlia, 1991-
dc.contributor.author Pérez Mañá, Clara
dc.contributor.author Ventura, Mireia
dc.contributor.author Carbón Mallol, Xoán
dc.contributor.author Grifell Guardia, Marc
dc.contributor.author Fonseca Casals, Francina, 1972-
dc.contributor.author Torrens, Marta
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Farré Albaladejo, Magí
dc.date.accessioned 2021-10-18T06:38:01Z
dc.date.available 2021-10-18T06:38:01Z
dc.date.issued 2021
dc.identifier.citation Poyatos L, Papaseit E, Olesti E, Pérez-Mañá C, Ventura M, Carbón X, Grifell M, Fonseca F, Torrens M, de la Torre R, Farré M. A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure. Biology (Basel). 2021;10(8):788. DOI: 10.3390/biology10080788
dc.identifier.issn 2079-7737
dc.identifier.uri http://hdl.handle.net/10230/48674
dc.description.abstract Considered the β-keto analogue of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), 3,4-Methylenedioxymethcathinone (methylone) is a synthetic cathinone. Over the years, methylone has been used as a substitute for conventional psychostimulants, such as MDMA. To date, little is known about the human pharmacology of methylone; the only available information has been provided by surveys or published intoxication reports. In the present observational-naturalistic study, we evaluate the acute subjective and physiological effects of methylone after oral self-administration in comparison to MDMA in healthy poly-drug users. Fourteen participants (10 males, 4 females) selected their single oral doses of methylone from 100 to 300 mg (n = 8, mean dose 187.5 mg) or MDMA from 75 to 100 mg (n = 6, mean dose 87.5 mg) based on their experience. Study variables were assessed at 0, 1, 2, and 4 h (h) and included vital signs (non-invasive blood pressure, heart rate, cutaneous temperature) and subjective effects using visual analogue scales (VAS), the 49-item Addiction Research Centre Inventory (ARCI) short form, and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) questionnaire. Additionally, oral fluid concentrations of methylone and MDMA were determined. Acute pharmacological effects produced by methylone followed the prototypical psychostimulant and empathogenic profile associated with MDMA, although they were less intense. Methylone concentrations in oral fluid can be considered a useful biomarker to detect acute exposure in oral fluid. Oral fluid concentrations of MDMA and methylone peaked at 2 h and concentrations of MDMA were in the range of those previously described in controlled studies. Our results demonstrate that the potential abuse liability of methylone is similar to that of MDMA in recreational subjects.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Biology (Basel). 2021;10(8):788
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title A comparison of acute pharmacological effects of methylone and MDMA administration in humans and oral fluid concentrations as biomarkers of exposure
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/biology10080788
dc.subject.keyword MDMA (3,4-methylenedioxymethamphetamine)
dc.subject.keyword Bath salts
dc.subject.keyword Methylone (3,4-methylenedioxymethcathinone)
dc.subject.keyword New psychoactive substances (NPS)
dc.subject.keyword Psychostimulants
dc.subject.keyword Synthetic cathinones
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking