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Exercise training-induced extracellular matrix protein adaptation in locomotor muscles: a systematic review

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dc.contributor.author Kritikaki, Efpraxia
dc.contributor.author Asterling, Rhiannon
dc.contributor.author Ward, Lesley
dc.contributor.author Padget, Kay
dc.contributor.author Barreiro Portela, Esther
dc.contributor.author Simoes, Davina C.M.
dc.date.accessioned 2021-09-06T06:58:59Z
dc.date.available 2021-09-06T06:58:59Z
dc.date.issued 2021
dc.identifier.citation Kritikaki E, Asterling R, Ward L, Padget K, Barreiro E, Simoes DCM. Exercise training-induced extracellular matrix protein adaptation in locomotor muscles: a systematic review. Cells. 2021;10(5):1022. DOI: 10.3390/cells10051022
dc.identifier.issn 2073-4409
dc.identifier.uri http://hdl.handle.net/10230/48393
dc.description.abstract Exercise training promotes muscle adaptation and remodelling by balancing the processes of anabolism and catabolism; however, the mechanisms by which exercise delays accelerated muscle wasting are not fully understood. Intramuscular extracellular matrix (ECM) proteins are essential to tissue structure and function, as they create a responsive environment for the survival and repair of the muscle fibres. However, their role in muscle adaptation is underappreciated and underinvestigated. The PubMed, COCHRANE, Scopus and CIHNAL databases were systematically searched from inception until February 2021. The inclusion criteria were on ECM adaptation after exercise training in healthy adult population. Evidence from 21 studies on 402 participants demonstrates that exercise training induces muscle remodelling, and this is accompanied by ECM adaptation. All types of exercise interventions promoted a widespread increase in collagens, glycoproteins and proteoglycans ECM transcriptomes in younger and older participants. The ECM controlling mechanisms highlighted here were concerned with myogenic and angiogenic processes during muscle adaptation and remodelling. Further research identifying the mechanisms underlying the link between ECMs and muscle adaptation will support the discovery of novel therapeutic targets and the development of personalised exercise training medicine.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Cells. 2021;10(5):1022
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Exercise training-induced extracellular matrix protein adaptation in locomotor muscles: a systematic review
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/cells10051022
dc.subject.keyword Adaptation
dc.subject.keyword Ageing
dc.subject.keyword Collagens
dc.subject.keyword Exercise training
dc.subject.keyword Extracellular matrix
dc.subject.keyword Glycoproteins
dc.subject.keyword Myogenesis
dc.subject.keyword Proteoglycans
dc.subject.keyword Remodelling
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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