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dc.contributor.author | Marhuenda Muñoz, María |
dc.contributor.author | Malcampo, Mireia |
dc.contributor.author | Zomeño Fajardo, Maria Dolores |
dc.contributor.author | Schröder, Helmut, 1958- |
dc.contributor.author | Fitó Colomer, Montserrat |
dc.contributor.author | Lamuela-Raventós, Rosa M. |
dc.date.accessioned | 2021-08-31T06:30:28Z |
dc.date.available | 2021-08-31T06:30:28Z |
dc.date.issued | 2021 |
dc.identifier.citation | Marhuenda-Muñoz M, Rinaldi de Alvarenga JF, Hernáez Á, Tresserra-Rimbau A, Martínez-González MÁ, Salas-Salvadó J et al. High fruit and vegetable consumption and moderate fat intake are associated with higher carotenoid concentration in human plasma. Antioxidants (Basel). 2021;10(3):473. DOI: 10.3390/antiox10030473 |
dc.identifier.issn | 2076-3921 |
dc.identifier.uri | http://hdl.handle.net/10230/48348 |
dc.description.abstract | Carotenoids are pigments contained mainly in fruit and vegetables (F&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase their bioavailability via facilitating transfer to the aqueous micellar phase during digestion. However, the extent to which high fat intake may contribute to increased carotenoid plasma concentrations is still unclear. The objective was to examine the degree to which the consumption of different amounts of both carotenoid-rich foods and fats is associated with plasma carotenoid concentrations within a Mediterranean lifestyle context (subsample from the PREDIMED-Plus study baseline) where consumption of F&V and fat is high. The study population was categorized into four groups according to their self-reported consumption of F&V and fat. Carotenoids were extracted from plasma samples and analyzed by HPLC-UV-VIS-QqQ-MS/MS. Carotenoid systemic concentrations were greater in high consumers of F&V than in low consumers of these foods (+3.04 μmol/L (95% CI: 0.90, 5.17), p-value = 0.005), but circulating concentrations seemed to decrease when total fat intake was very high (-2.69 μmol/L (-5.54; 0.16), p-value = 0.064). High consumption of F&V is associated with greater systemic levels of total carotenoids, in particular when fat intake is low-to-moderate rather than very high. |
dc.description.sponsorship | The PREDIMED-Plus trial was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated Fondo de Investigaciones Sanitarias projects lead by J.S.-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926 and PI19/00781), the Especial Action Project entitled Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S., European Research Council (Advanced Research Grant 2014–2019, 340918) to M.Á.M.-G., the Recercaixa grant to J.S.-S. (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, Fundació la Marató de TV3 (PI044003), 2017 SGR 1717 from Generalitat de Catalunya, a CICYT grant provided by the Ministerio de Ciencia, Innovación y Universidades (AGL2016-75329-R), and funds from the European Regional Development Fund (CB06/03). Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil, and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts. J.K. was supported by the “FOLIUM” program within the FUTURMed project entitled Talent for the medicine within the future from the Fundació Institut d’Investigació Sanitària Illes Balears. This call was co-financed at 50% with charge to the Operational Program FSE 2014-2020 of the Balearic Islands. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartof | Antioxidants (Basel). 2021;10(3):473 |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.title | High fruit and vegetable consumption and moderate fat intake are associated with higher carotenoid concentration in human plasma |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.3390/antiox10030473 |
dc.subject.keyword | Mediterranean diet |
dc.subject.keyword | PREDIMED-Plus study |
dc.subject.keyword | Bioactive compounds |
dc.subject.keyword | Dietary fats |
dc.subject.keyword | Liquid chromatography |
dc.subject.keyword | Mass spectrometry |
dc.subject.keyword | Matrix effect absorption |
dc.subject.keyword | Phytochemicals |
dc.subject.keyword | Plasma carotenoids |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-R |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/340918 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |