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Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health

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dc.contributor.author Forner, Mar
dc.contributor.author Cañas Arranz, Rodrigo
dc.contributor.author Defaus, Sira
dc.contributor.author de León, Patricia
dc.contributor.author Rodríguez Pulido, Miguel
dc.contributor.author Ganges, Lliliane
dc.contributor.author Blanco, Esther
dc.contributor.author Sobrino, Francisco
dc.contributor.author Andreu Martínez, David
dc.date.accessioned 2021-08-04T05:58:12Z
dc.date.available 2021-08-04T05:58:12Z
dc.date.issued 2021
dc.identifier.citation Forner M, Cañas-Arranz R, Defaus S, de León P, Rodríguez-Pulido M, Ganges L, Blanco E, Sobrino F, Andreu D. Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health. Vaccines (Basel). 2021;9(5):477. DOI: 10.3390/vaccines9050477
dc.identifier.issn 2076-393X
dc.identifier.uri http://hdl.handle.net/10230/48310
dc.description.abstract Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden of infectious diseases. However, few vaccines are fully effective, for reasons ranging from intrinsic limitations to more contingent shortcomings related, e.g., to cold chain transport, handling and storage. In this context, subunit vaccines where the essential antigenic traits (but not the entire pathogen) are presented in rationally designed fashion have emerged as an attractive alternative to conventional ones. In particular, this includes the option of fully synthetic peptide vaccines able to mimic well-defined B- and T-cell epitopes from the infectious agent and to induce protection against it. Although, in general, linear peptides have been associated to low immunogenicity and partial protection, there are several strategies to address such issues. In this review, we report the progress towards the development of peptide-based vaccines against foot-and-mouth disease (FMD) a highly transmissible, economically devastating animal disease. Starting from preliminary experiments using single linear B-cell epitopes, recent research has led to more complex and successful second-generation vaccines featuring peptide dendrimers containing multiple copies of B- and T-cell epitopes against FMD virus or classical swine fever virus (CSFV). The usefulness of this strategy to prevent other animal and human diseases is discussed.
dc.description.sponsorship This research was funded by the European Commission (project H2020-FETOPEN-2018-2019-2020-01 n° 828774), by the Spanish Ministry of Science, Innovation and Universities, grants AGL2014-48923-C2 and AGL2017-84097-C2-2-R (to D.A. and F.S.), and AGL2016-349 76445-R (to E.B.), as well as by Comunidad de Madrid co-financed ECFEDER funds (S2013/ABI-350 2906-PLATESA and P2018/BAA-4370 to F.S. and E.B.), and by Generalitat de Catalunya (2009SGR492 to D.A.). Work at Centro de Biología Molecular “Severo Ochoa” and at UPF was supported by Fundación Ramón Areces and by the Maria de Maeztu Program of the Spanish Ministry of Science, Innovation and Universities, respectively. M.F. and R.C.-A. were holders of a PhD fellowship from the Spanish Ministry of Science, Innovation and Universities.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Vaccines (Basel). 2021;9(5):477
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Peptide-based vaccines: foot-and-mouth disease virus, a paradigm in animal health
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/vaccines9050477
dc.subject.keyword FMDV
dc.subject.keyword Epitope-based vaccines
dc.subject.keyword Peptide
dc.subject.keyword Vaccines
dc.subject.keyword Veterinary medicine
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/828774
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2014-48923-C2
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/AGL2017-84097-C2-2-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2016-349 76445-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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