Welcome to the UPF Digital Repository

p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases

Show simple item record

dc.contributor.author Rakislova, Natalia
dc.contributor.author Alemany, Laia
dc.contributor.author Clavero, Omar
dc.contributor.author Saco, Adela
dc.contributor.author Torné, Aureli
dc.contributor.author Pino, Marta Del
dc.contributor.author Munmany, Meritxell
dc.contributor.author Rodrigo Calvo, Maria Teresa
dc.contributor.author Guerrero, José
dc.contributor.author Marimon, Lorena
dc.contributor.author Vega, Naiara
dc.contributor.author Quirós, Beatriz
dc.contributor.author Lloveras Rubio, Belen
dc.contributor.author Ribera-Cortada, Inmaculada
dc.contributor.author Alejo, María
dc.contributor.author Pawlita, Michael
dc.contributor.author Quint, Wim
dc.contributor.author Sanjosé Llongueras, Silvia de
dc.contributor.author Ordi, Jaume
dc.contributor.author Vvap Study Group
dc.date.accessioned 2021-07-22T07:11:48Z
dc.date.available 2021-07-22T07:11:48Z
dc.date.issued 2020
dc.identifier.citation Rakislova N, Alemany L, Clavero O, Saco A, Torné A, Del Pino M, et al. p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases. Int J Mol Sci. 2020 Oct 29;21(21): 8091. DOI: 10.3390/ijms21218091
dc.identifier.issn 1422-0067
dc.identifier.uri http://hdl.handle.net/10230/48275
dc.description.abstract Human papillomavirus (HPV)-independent vulvar squamous cell carcinomas (VSCC) and its precursors frequently harbour TP53 mutations. Recently, six p53 immunohistochemical (IHC) patterns have been defined, which have shown strong correlation with TP53 mutation status. However, few studies have applied this new six-pattern framework and none of them exhaustively compared p53 IHC positivity and patterns between invasive VSCC and adjacent skin lesion. We performed p53 IHC in a series of 779 HPV-independent VSCC with adjacent skin and evaluated the IHC slides following the newly described classification. Some 74.1% invasive VSCC showed abnormal p53 IHC staining. A skin lesion was identified in 450 cases (57.8%), including 254 intraepithelial precursors and 196 inflammatory/reactive lesions. Two hundred and ten of 450 (47%) VSCC with associated skin lesions showed an abnormal p53 IHC stain, with an identical staining pattern between the VSCC and the adjacent skin lesion in 80% of the cases. A total of 144/450 (32%) VSCC showed wild-type p53 IHC both in the invasive VSCC and adjacent skin lesion. Finally, 96/450 (21%) VSCC showed p53 IHC abnormal staining in the invasive VSCC but a wild-type p53 staining in the skin lesion. Most of the discordant cases (70/96; 73%) showed adjacent inflammatory lesions. In conclusion, the p53 IHC staining and pattern are usually identical in the VSCC and the intraepithelial precursor.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title p53 immunohistochemical patterns in HPV-independent squamous cell carcinomas of the vulva and the associated skin lesions: a study of 779 cases
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijms21218091
dc.subject.keyword HPV-independent vulvar cancer
dc.subject.keyword TP53
dc.subject.keyword p53
dc.subject.keyword Vulvar squamous cell carcinoma
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking