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Gut microbiota profile and changes in body weight in elderly subjects with overweight/obesity and metabolic syndrome

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dc.contributor.author Atzeni, Alessandro
dc.contributor.author Galié, Serena
dc.contributor.author Muralidharan, Jananee
dc.contributor.author Babio, Nancy
dc.contributor.author Tinahones Madueño, Francisco José
dc.contributor.author Vioque, Jesus
dc.contributor.author Corella, Dolores
dc.contributor.author Castañer, Olga
dc.contributor.author Vidal Alaball, Josep
dc.contributor.author Moreno Indias, Isabel
dc.contributor.author Torres-Collado, Laura
dc.contributor.author Fernández-Carrión, Rebeca
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Olbeyra, Romina
dc.contributor.author Martínez-González, Miguel A.
dc.contributor.author Bulló, Mònica
dc.contributor.author Salas Salvadó, Jordi
dc.date.accessioned 2021-07-05T06:57:54Z
dc.date.available 2021-07-05T06:57:54Z
dc.date.issued 2021
dc.identifier.citation Atzeni A, Galié S, Muralidharan J, Babio N, Tinahones FJ, Vioque J, Corella D, Castañer O, Vidal J, Moreno-Indias I, Torres-Collado L, Fernández-Carrión R, Fitó M, Olbeyra R, Martínez-González MA, Bulló M, Salas-Salvadó J. Gut microbiota profile and changes in body weight in elderly subjects with overweight/obesity and metabolic syndrome. Microorganisms. 2021;9(2):346. DOI: 10.3390/microorganisms9020346
dc.identifier.issn 2076-2607
dc.identifier.uri http://hdl.handle.net/10230/48071
dc.description.abstract Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.
dc.description.sponsorship This research was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 713679 and from the Universitat Rovira i Virgili (URV). This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (three coordinated FIS projects leaded by J.S.-S., including the following projects: PI13/00462, PI16/00501 and PI19/00576); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to J.S.-S.; the Recercaixa (number 2013ACUP00194) grant to J.S.-S.; The Fondo de Investigaciones Sanitarias of the Instituto de Salut Carlos III PI17/00215; The Generalitat Valenciana PROMETEO 17/2017. None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication. J.S.-S., senior author of this study gratefully acknowledges the financial support by ICREA under the ICREA Academia programme. Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil; and the Almond Board of California (Modesto, CA), American Pistachio Growers (Fresno, CA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA) donated nuts for the PREDIMED-Pilot study.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Microorganisms. 2021;9(2):346
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Gut microbiota profile and changes in body weight in elderly subjects with overweight/obesity and metabolic syndrome
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/microorganisms9020346
dc.subject.keyword 16S sequencing
dc.subject.keyword BMI
dc.subject.keyword Clinical trial
dc.subject.keyword Gut microbiota
dc.subject.keyword Obesity
dc.subject.keyword Weight loss
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/713679
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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