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Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis

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dc.contributor.author de Jesús-Gil, Carmen
dc.contributor.author Sans-de San Nicolás, Lídia
dc.contributor.author Ruiz-Romeu, Ester
dc.contributor.author Ferran Farrés, Marta
dc.contributor.author Soria-Martinez, Laura
dc.contributor.author García Jiménez, Irene
dc.contributor.author Chiriac, Anca
dc.contributor.author Casanova Seuma, Josep Manel
dc.contributor.author Fernández Armenteros, José Manuel
dc.contributor.author Owens, Sherry
dc.contributor.author Celada, Antonio
dc.contributor.author Howell, Michael D.
dc.contributor.author Pujol Vallverdú, Ramon Maria
dc.contributor.author Santamaría-Babí, Luis Francisco
dc.date.accessioned 2021-06-22T06:52:28Z
dc.date.available 2021-06-22T06:52:28Z
dc.date.issued 2021
dc.identifier.citation de Jesús-Gil C, Sans-de San Nicolàs L, Ruiz-Romeu E, Ferran M, Soria-Martínez L, García-Jiménez I, Chiriac A, Casanova-Seuma JM, Fernández-Armenteros JM, Owens S, Celada A, Howell MD, Pujol RM, Santamaria-Babí LF. Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis. Int J Mol Sci. 2021;22(4):1519. DOI: 10.3390/ijms22041519
dc.identifier.issn 1422-0067
dc.identifier.uri http://hdl.handle.net/10230/47957
dc.description.abstract Candida albicans (CA) infections have been associated with psoriasis onset or disease flares. However, the integrated immune response against this fungus is still poorly characterized in psoriasis. We studied specific immunoglobulins in plasma and the CA response in cocultures of circulating memory CD45RA- cutaneous lymphocyte antigen (CLA)+/- T cell with autologous epidermal cells from plaque and guttate psoriasis patients (cohort 1, n = 52), and also healthy individuals (n = 17). A complete proteomic profile was also evaluated in plaque psoriasis patients (cohort 2, n = 114) regarding their anti-CA IgA levels. Increased anti-CA IgA and IgG levels are present in the plasma from plaque but not guttate psoriasis compared to healthy controls. CA cellular response is confined to CLA+ T cells and is primarily Th17. The levels of anti-CA IgA are directly associated with CLA+ Th17 response in plaque psoriasis. Proteomic analysis revealed distinct profiles in psoriasis patients with high anti-CA IgA. C-C motif chemokine ligand 18, chitinase-3-like protein 1 and azurocidin were significantly elevated in the plasma from plaque psoriasis patients with high anti-CA levels and severe disease. Our results indicate a mechanism by which Candida albicans exposure can trigger a clinically relevant IL-17 response in psoriasis. Assessing anti-CA IgA levels may be useful in order to evaluate chronic psoriasis patients.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Int J Mol Sci. 2021;22(4):1519
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Interplay between Humoral and CLA + T Cell Response against Candida albicans in Psoriasis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijms22041519
dc.subject.keyword CLA
dc.subject.keyword Candida albicans
dc.subject.keyword IL-17
dc.subject.keyword IgA
dc.subject.keyword Psoriasis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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