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dc.contributor.author Baquero Pérez, Belinda
dc.contributor.author Geers, Daryl
dc.contributor.author Díez Antón, Juana, 1962-
dc.date.accessioned 2021-06-21T07:50:39Z
dc.date.available 2021-06-21T07:50:39Z
dc.date.issued 2021
dc.identifier.citation Baquero-Pérez B, Geers D, Díez J. From A to m6A: the emerging viral epitranscriptome. Viruses. 2021;13(6):1049. DOI: 10.3390/v13061049
dc.identifier.issn 1999-4915
dc.identifier.uri http://hdl.handle.net/10230/47945
dc.description.abstract There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that m6A modifications play important roles in regulating viral replication by interacting with the cellular m6A machinery. In this review, we will exhaustively detail the current knowledge on m6A modification, with an emphasis on its function in virus biology.
dc.description.sponsorship This work was supported by the Spanish Ministry of Science and Innovation through grants PID2019-106959RB-I00/AEI/10.13039/501100011033, an institutional “Maria de Maeztu” Programme for Units of Excellence in R&D (CEX2018-000792-M), by the 2017 SGR 909 grant from the Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement of the Generalitat de Catalunya and a Beatriu Pinós postdoctoral fellowship awarded to Belinda Baquero-Perez which is funded by the Secretary of Universities and Research (Government of Catalonia) and by the Horizon 2020 programme of research and innovation of the European Union under the Marie Sklodowska-Curie grant agreement No 801370. All figures in this review were drawn using BioRender.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Viruses. 2021;13(6):1049
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title From A to m6A: the emerging viral epitranscriptome
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/v13061049
dc.subject.keyword m6A
dc.subject.keyword Viral infection
dc.subject.keyword Epitranscriptomics
dc.subject.keyword RNA modification
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/801370
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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