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Polyphenol intake and gastric cancer risk: findings from the stomach cancer pooling project (StoP)

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dc.contributor.author Vitelli-Storelli, Facundo
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Martín Sánchez, Vicente
dc.date.accessioned 2021-06-08T06:49:07Z
dc.date.available 2021-06-08T06:49:07Z
dc.date.issued 2020
dc.identifier.citation Vitelli-Storelli F, Rossi M, Pelucchi C, Rota M, Palli D, Ferraroni M, et al. Polyphenol intake and gastric cancer risk: findings from the stomach cancer pooling project (StoP). Cancers (Basel). 2020 Oct 20; 12(10): 3064. DOI: 10.3390/cancers12103064
dc.identifier.issn 2072-6694
dc.identifier.uri http://hdl.handle.net/10230/47786
dc.description.abstract Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54-0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55-0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56-0.92), flavanols (OR = 0.77, 95% CI = 0.66-0.88), flavanones (OR = 0.57, 95%CI = 0.44-0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55-0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57-0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51-1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58-1.06). Further investigations from longitudinal data are needed to confirm this association.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Polyphenol intake and gastric cancer risk: findings from the stomach cancer pooling project (StoP)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/cancers12103064
dc.subject.keyword Diet
dc.subject.keyword Epidemiology
dc.subject.keyword Flavonoids
dc.subject.keyword Gastric cancer
dc.subject.keyword Polyphenols
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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