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Cost of early-stage mycosis fungoides treatments in Spain

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dc.contributor.author Ortiz-Romero, Pablo L.
dc.contributor.author Servitje, Octavio
dc.contributor.author Estrach, Teresa
dc.contributor.author Izu-Belloso, Rosa María
dc.contributor.author Fernández-de-Misa, Ricardo
dc.contributor.author Gallardo Hernández, Fernando
dc.contributor.author López-Martínez, Noemí
dc.contributor.author Pérez-Mitru, Alejandro
dc.date.accessioned 2021-05-03T07:41:08Z
dc.date.available 2021-05-03T07:41:08Z
dc.date.issued 2020
dc.identifier.citation Ortiz-Romero PL, Servitje O, Estrach MT, Izu-Belloso RM, Fernández-de-Misa R, Gallardo F, et al. Cost of early-stage mycosis fungoides treatments in Spain. Clinicoecon Outcomes Res. 2020 Feb 12; 12: 91-105. DOI: 10.2147/CEOR.S233376
dc.identifier.issn 1178-6981
dc.identifier.uri http://hdl.handle.net/10230/47274
dc.description.abstract Aim: To identify the most common therapeutic options for the treatment of early-stage mycosis fungoides in Spain, quantify their associated healthcare resource use and costs. Methods: After reviewing the literature, a panel of 6 Spanish clinical dermatologists validated the treatments and healthcare resource use through a structured questionnaire. Individual responses were collected, analyzed and presented into a face-to-face meeting in order to reach a consensus. Cost categories considered were: drug acquisition and administration, photo/radiotherapy session and maintenance, clinical follow-up visits and laboratory tests. Costs were expressed in euros from 2018. The Spanish National Health System perspective was considered, taking into account direct health costs and time horizons of 1, 3 and 6 months. Results: Costs for the skin-directed treatments (SDT) assessed at 1, 3 and 6 months, were: Topical carmustine [€6,593.36, €19,780.09 and €27,592.78]; Phototherapy with psoralens and ultraviolet A light (PUVA) [€1,098.68, €2,999.99 and €3,187.60]; Narrow-band ultraviolet B phototherapy [€1,657.47, €4,842.10 and €4,842.10]; Total skin electron beam therapy (TSEBT) [€6,796.45, €7,913.34 and €7,913.34]. Cost for topical corticosteroids, being considered an adjuvant option, were €17.16, €51.49 and €102.97. Costs for the assessed systemic treatments alone or in combination with SDT at 1, 3 and 6 months, were: Systemic retinoids [€2,026.03, €5,206.63 and €7,426.42]; Systemic retinoids + PUVA phototherapy [€3,066.50, €8,271.26 and €10,046.58]; Interferon alfa + PUVA phototherapy [€1,541.09, €5,167.57 and €6,404.55]. Conclusion: According to the Spanish clinical practice, phototherapies in monotherapy were the treatments with the lowest associated costs regardless of the time horizon considered. TSEBT turned out as the treatment with the highest associated costs when considering 1 month. However, while considering 3 and 6 months the treatment with the highest associated costs was topical carmustine. The results of this analysis may provide critical information to measure the disease burden, to detect unmet medical needs and to advocate towards better treatments for this rare disease.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Dove Medical Press
dc.rights Copyright © 2020 Ortiz-Romero et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
dc.title Cost of early-stage mycosis fungoides treatments in Spain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.2147/CEOR.S233376
dc.subject.keyword Spain
dc.subject.keyword T-cell
dc.subject.keyword Cutaneous
dc.subject.keyword Health care costs
dc.subject.keyword Health resources
dc.subject.keyword Lymphoma
dc.subject.keyword Mycosis fungoides
dc.subject.keyword Surveys and questionnaires
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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