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Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals

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dc.contributor.author Hahn, Gerald
dc.contributor.author Zamora-López, Gorka
dc.contributor.author Uhrig, Lynn
dc.contributor.author Tagliazucchi, Enzo
dc.contributor.author Laufs, Helmut
dc.contributor.author Mantini, Dante
dc.contributor.author Kringelbach, Morten L.
dc.contributor.author Jarraya, Béchir
dc.contributor.author Deco, Gustavo
dc.date.accessioned 2021-03-15T08:14:07Z
dc.date.available 2021-03-15T08:14:07Z
dc.date.issued 2021
dc.identifier.citation Hahn G, Zamora-López G, Uhrig L, Tagliazucchi E, Laufs H, Mantini D, Kringelbach ML, Jarraya B, Deco G. Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals. Neuroimage. 2021 Feb 1;226:117470. DOI: 10.1016/j.neuroimage.2020.117470
dc.identifier.issn 1053-8119
dc.identifier.uri http://hdl.handle.net/10230/46764
dc.description.abstract During the sleep-wake cycle, the brain undergoes profound dynamical changes, which manifest subjectively as transitions between conscious experience and unconsciousness. Yet, neurophysiological signatures that can objectively distinguish different consciousness states based are scarce. Here, we show that differences in the level of brain-wide signals can reliably distinguish different stages of sleep and anesthesia from the awake state in human and monkey fMRI resting state data. Moreover, a whole-brain computational model can faithfully reproduce changes in global synchronization and other metrics such as functional connectivity, structure-function relationship, integration and segregation across vigilance states. We demonstrate that the awake brain is close to a Hopf bifurcation, which naturally coincides with the emergence of globally correlated fMRI signals. Furthermore, simulating lesions of individual brain areas highlights the importance of connectivity hubs in the posterior brain and subcortical nuclei for maintaining the model in the awake state, as predicted by graph-theoretical analyses of structural data.
dc.description.sponsorship G.D. was supported by the Spanish Research Project AWAKENING: using whole-brain models perturbational approaches for predicting external stimulation to force transitions between different brain states, ref. PID2019-105772GB-I00 /AEI/10.13039/501100011033, financed by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI), and by the Catalan AGAUR program 2017 SGR 1545. G.D., G.H. and G.Z. received support from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 720270 (Human Brain Project SGA1), No. 785907 (Human Brain Project SGA2) and No. 945539 (Human Brain Project SGA3). G.H. was funded by the grant CONSCBRAIN (n. 661583) of the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie action. G.D. and G.H. received funding from the German Research Council (DFG, No. KN 588/7 – 1) within the priority program Computational Connectomics (SPP 2041). E.T. and H.L. were supported by the Bundesministerium für Bildung und Forschung (grant number 01 EV 0703) and the LOEWE Neuronale Koordination Forschungsschwerpunkt Frankfurt (NeFF). M.L.K. is supported by the ERC Consolidator Grant: CAREGIVING (n. 615539), Center for Music in the Brain, funded by the Danish National Research Foundation (DNRF117), and centre for Eudaimonia and Human Flourishing funded by the Pettit and Carlsberg Foundations.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Neuroimage. 2021 Feb 1;226:117470
dc.rights © 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2020.117470
dc.subject.keyword Brain Mapping
dc.subject.keyword Cortical Synchronization
dc.subject.keyword Haplorhini
dc.subject.keyword Magnetic Resonance Imaging
dc.subject.keyword Consciousness
dc.subject.keyword Unconsciousness
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/720270
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785907
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/945539
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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