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Shared DNA methylation signatures in childhood allergy: The MeDALL study

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dc.contributor.author Xu, Cheng-Jian
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Koppelman, Gerard H.
dc.date.accessioned 2021-03-10T06:52:43Z
dc.date.available 2021-03-10T06:52:43Z
dc.date.issued 2021
dc.identifier.citation Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A et al. Shared DNA methylation signatures in childhood allergy: The MeDALL study. J Allergy Clin Immunol. 2021; 147(3):1031-40. DOI: 10.1016/j.jaci.2020.11.044
dc.identifier.issn 0091-6749
dc.identifier.uri http://hdl.handle.net/10230/46708
dc.description.abstract Background: Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema. Objective: We sought to identify DNA methylation profiles associated with childhood allergy. Methods: Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discovery study included 219 case patients and 417 controls at age 4 years and 228 case patients and 593 controls at age 8 years from 3 birth cohorts, with replication analyses in 325 case patients and 1111 controls. We performed additional analyses on 21 replicated sites in 785 case patients and 2124 controls by allergic symptoms only from 8 cohorts, 3 of which were not previously included in analyses. Results: We identified 80 differentially methylated CpG sites that showed a 1% to 3% methylation difference in the discovery phase, of which 21 (including 5 novel CpG sites) passed genome-wide significance after meta-analysis. All 21 CpG sites were also significantly differentially methylated with allergic symptoms and shared between asthma, rhinitis, and eczema. The 21 CpG sites mapped to relevant genes, including ACOT7, LMAN3, and CLDN23. All 21 CpG sties were differently methylated in asthma in isolated eosinophils, and 10 were replicated in respiratory epithelium. Conclusion: Reduced whole blood DNA methylation at 21 CpG sites was significantly associated with childhood allergy. The findings provide novel insights into the shared molecular mechanisms underlying asthma, rhinitis, and eczema.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof J Allergy Clin Immunol. 2021; 147(3):1031-40.
dc.rights © 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy ofAllergy, Asthma & Immunology. This is an open access article under the CC BY li-cense (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Shared DNA methylation signatures in childhood allergy: The MeDALL study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jaci.2020.11.044
dc.subject.keyword DNA methylation
dc.subject.keyword Epigenetics
dc.subject.keyword IgE
dc.subject.keyword Allergy
dc.subject.keyword Children
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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