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Electric field causes volumetric changes in the human brain

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dc.contributor.author Argyelan, Miklos
dc.contributor.author Pujol Nuez, Jesús
dc.contributor.author Abbott, Christopher
dc.date.accessioned 2021-03-01T07:52:12Z
dc.date.available 2021-03-01T07:52:12Z
dc.date.issued 2019
dc.identifier.citation Argyelan M, Oltedal L, Deng ZD, Wade B, Bikson M, Joanlanne A, et al. Electric field causes volumetric changes in the human brain. Elife. 2019 Oct 23; 8: e49115. DOI: 10.7554/eLife.49115
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/46617
dc.description.abstract Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.rights This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. http://creativecommons.org/publicdomain/zero/1.0/
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
dc.title Electric field causes volumetric changes in the human brain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.49115
dc.subject.keyword ECT
dc.subject.keyword Depression
dc.subject.keyword Electric field modeling
dc.subject.keyword Human
dc.subject.keyword Human biology
dc.subject.keyword Medicine
dc.subject.keyword Neuroimaging
dc.subject.keyword Volume change
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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