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dc.contributor.author Frankish, Adam
dc.contributor.author Lagarde, Julien
dc.contributor.author Carbonell Sala, Silvia
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Flicek, Paul
dc.date.accessioned 2021-02-16T07:02:19Z
dc.date.available 2021-02-16T07:02:19Z
dc.date.issued 2021
dc.identifier.citation Frankish A, Diekhans M, Jungreis I, Lagarde J, Loveland JE, Mudge JM et al. GENCODE 2021. Nucleic Acids Res. 2021; 49(D1):D916-D923. DOI: 10.1093/nar/gkaa1087
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/10230/46485
dc.description.abstract The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation processes make use of primary data and bioinformatic tools and analysis generated both within the consortium and externally to support the creation of transcript structures and the determination of their function. Here, we present improvements to our annotation infrastructure, bioinformatics tools, and analysis, and the advances they support in the annotation of the human and mouse genomes including: the completion of first pass manual annotation for the mouse reference genome; targeted improvements to the annotation of genes associated with SARS-CoV-2 infection; collaborative projects to achieve convergence across reference annotation databases for the annotation of human and mouse protein-coding genes; and the first GENCODE manually supervised automated annotation of lncRNAs. Our annotation is accessible via Ensembl, the UCSC Genome Browser and https://www.gencodegenes.org.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Nucleic Acids Res. 2021; 49(D1):D916-D923
dc.rights © The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title GENCODE 2021
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/nar/gkaa1087
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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