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Physical activity and lung function-Cause or consequence?

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dc.contributor.author Bédard, Annabelle, 1986-
dc.contributor.author Carsin, Anne-Elie
dc.contributor.author Fuertes, Elaine
dc.contributor.author Accordini, Simone
dc.contributor.author Dharmage, Shyamali C.
dc.contributor.author Garcia Larsen, Vanessa
dc.contributor.author Heinrich, Joachim
dc.contributor.author Janson, Christer
dc.contributor.author Johannessen, Ane
dc.contributor.author Leynaert, Bénédicte
dc.contributor.author Sánchez-Ramos, José Luis
dc.contributor.author Peralta, Gabriela P.
dc.contributor.author Pin, Isabelle
dc.contributor.author Squillacioti, Giulia
dc.contributor.author Weyler, Joost
dc.contributor.author Jarvis, Deborah
dc.contributor.author García Aymerich, Judith
dc.date.accessioned 2021-01-25T07:30:56Z
dc.date.available 2021-01-25T07:30:56Z
dc.date.issued 2020
dc.identifier.citation Bédard A, Carsin AE, Fuertes E, Accordini S, Dharmage SC, Garcia-Larsen V, Heinrich J, Janson C, Johannessen A, Leynaert B, Sánchez-Ramos JL, Peralta GP, Pin I, Squillacioti G, Weyler J, Jarvis D, Garcia-Aymerich J. Physical activity and lung function-Cause or consequence? PLoS One. 2020; 15(8):e0237769. DOI: 10.1371/journal.pone.0237769
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/46259
dc.description.abstract Concerns exist that the positive association of physical activity with better lung function, which has been suggested in previous longitudinal studies in smokers, is due to reverse causation. To investigate this, we applied structural equation modeling (SEM), an exploratory approach, and marginal structural modeling (MSM), an approach from the causal inference framework that corrects for reverse causation and time-dependent confounding and estimates causal effects, on data from participants in the European Community Respiratory Health Survey (ECRHS, a multicentre European cohort study initiated in 1991-1993 with ECRHS I, and with two follow-ups: ECRHS II in 1999-2003, and ECRHS III in 2010-2014). 753 subjects who reported current smoking at ECRHS II, with repeated data on lung function at ECRHS I, II and III, physical activity at ECRHS II and III, and potential confounders at ECRHS I and II, were included in the analyses. SEM showed positive associations between physical activity and lung function in both directions. MSM suggested a protective causal effect of physical activity on lung function (overall difference in mean β (95% CI), comparing active versus non-active individuals: 58 mL (21-95) for forced expiratory volume in one second and 83 mL (36-130) for forced vital capacity). Our results suggest bi-directional causation and support a true protective effect of physical activity on lung function in smokers, after accounting for reverse causation and time-dependent confounding.
dc.description.sponsorship The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no 633212.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One. 2020; 15(8):e0237769
dc.rights © 2020 Bédard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Physical activity and lung function-Cause or consequence?
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0237769
dc.subject.keyword Physical activity
dc.subject.keyword Pulmonary function
dc.subject.keyword Body weight
dc.subject.keyword Diet
dc.subject.keyword Respiratory infections
dc.subject.keyword Data management
dc.subject.keyword Nutrition
dc.subject.keyword Longitudinal studies
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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