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Occupational exposure to pesticides and chronic lymphocytic leukaemia in the MCC-Spain study

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dc.contributor.author Benavente, Yolanda
dc.contributor.author Vila Rodríguez, Javier, 1974-
dc.contributor.author Gimeno Vázquez, Eva
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Casabonne, Delphine
dc.date.accessioned 2020-11-03T07:40:22Z
dc.date.available 2020-11-03T07:40:22Z
dc.date.issued 2020
dc.identifier.citation Benavente Y, Costas L, Rodríguez-Suarez MM, Alguacil J, Santibáñez M, Vila J. et al. Occupational exposure to pesticides and chronic lymphocytic leukaemia in the MCC-Spain study. Int J Environ Res Public Health. 2020 Jul; 17(14):5174. DOI: 10.3390/ijerph17145174
dc.identifier.issn 1660-4601
dc.identifier.uri http://hdl.handle.net/10230/45644
dc.description.abstract We aimed to study the association between occupational exposure to pesticides and chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides, four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain, 2010-2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs the product of prevalence, intensity and duration of exposure to each active substance. Principal components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend; 2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA, the first component (PC1, explaining 70% of the variation) equally led by seven active substances (the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm previous associations between CLL and exposure to pesticides and provide additional evidence by application groups and active substance. However, more research is needed to disentangle independent effects of individual active substances.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof International Journal of Environmental Research and Public Health. 2020 Jul;17(14):5174
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Occupational exposure to pesticides and chronic lymphocytic leukaemia in the MCC-Spain study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijerph17145174
dc.subject.keyword Chronic lymphocytic leukemia
dc.subject.keyword Job-exposure matrix
dc.subject.keyword Occupational exposure
dc.subject.keyword Pesticides
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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