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Bioavailability of epigallocatechin gallate administered with different nutritional strategies in healthy volunteers

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dc.contributor.author Andreu Fernández, Vicente
dc.contributor.author Almeida Toledano, Laura
dc.contributor.author Pizarro Lozano, Mª Nieves
dc.contributor.author Navarro-Tapia, Elisabet
dc.contributor.author Gómez-Roig, María Dolores
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author García-Algar, Oscar
dc.date.accessioned 2020-10-13T09:29:11Z
dc.date.available 2020-10-13T09:29:11Z
dc.date.issued 2020
dc.identifier.citation Andreu-Fernández V, Almeida Toledano L, Pizarro N, Navarro-Tapia E, Gómez-Roig MD, de la Torre R. et al. Bioavailability of epigallocatechin gallate administered with different nutritional strategies in healthy volunteers. Antioxidants (Basel). 2020 May 19; 9(5):440. DOI: 10.3390/antiox9050440
dc.identifier.issn 2076-3921
dc.identifier.uri http://hdl.handle.net/10230/45467
dc.description.abstract The flavanol epigallocatechin gallate (EGCG) is being tested for the treatment of several diseases in humans. However, its bioavailability and pharmacokinetic profile needs a better understanding to enable its use in clinical trials. There is no consensus on the most appropriate concentration of EGCG in the body to obtain the maximum therapeutic effects. Therefore, the aim of this study is to analyze the bioavailability of EGCG orally administered alone or with different food supplements after overnight fasting in order to determine its optimal conditions (high concentrations in blood and the lowest interindividual variations) to be used as a pharmacological tool in human trials. Ten healthy volunteers (5 men and 5 women) aged 25 to 35 years were recruited prospectively. Three series of clinical experiments with a washout period of seven days among each were performed: 1) Teavigo® (EGCG extract) alone, 2) Teavigo® with a standard breakfast, and 3) FontUp® (Teavigo® commercially prepared with fats, carbohydrates, proteins, vitamins, and minerals). Blood samples were collected at 0, 30, 60, 90, 120, 180, 240, and 360 min after EGCG intake. Free EGCG in plasma was measured using a liquid chromatography and mass spectrometry UPLC-ESI-MS/MS analytical method. The pharmacokinetic variables analyzed statistically were area under the curve (AUC0-360), Cmax, Cav, Cmin, T1/2, and Tmax,. EGCG (Teavigo®) alone was the group with higher AUC0-360, Cmax, and Cav both in men (3.86 ± 4.11 µg/mL/kg/6 h; 5.95 ng/mL/kg; 2.96 ng/mL/kg) and women (3.33 ± 1.08 µg/mL/kg/6 h; 6.66 ng/mL/kg; 3.66 ng/mL). Moreover, FontUp® was the group with the highest value of T1/2 both in men (192 ± 66 min) and women (133 ± 28 min). Teavigo® intake after fasting overnight revealed the highest concentration of EGCG in plasma according to its pharmacokinetic profile, indicating that this is an excellent alternative of administration if the experimental design requires good absorption in the gastrointestinal tract. Moreover, EGCG taken along with food supplements (FontUp®) improved the stability of the molecule in the body, being the best choice if the experimental design wants to reduce interindividual variation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Antioxidants (Basel). 2020 May 19;9(5):440
dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Bioavailability of epigallocatechin gallate administered with different nutritional strategies in healthy volunteers
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/antiox9050440
dc.subject.keyword EGCG
dc.subject.keyword Epigallocatechin Gallate
dc.subject.keyword Teavigo®
dc.subject.keyword Bioavailability
dc.subject.keyword Antioxidants
dc.subject.keyword Catechins
dc.subject.keyword Food supplement
dc.subject.keyword Green tea
dc.subject.keyword Pharmacokinetic profile
dc.subject.keyword Polyphenols
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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