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dc.contributor.author | Tang, Jun |
dc.contributor.author | Ramis Cabrer, Daniel, 1993- |
dc.contributor.author | Curull Serrano, Víctor |
dc.contributor.author | Wang, Xuejie |
dc.contributor.author | Qin, Liyun |
dc.contributor.author | Mateu Jiménez, Mercè, 1990- |
dc.contributor.author | Duran Jordà, Xavier, 1974- |
dc.contributor.author | Pijuan Andujar, Lara |
dc.contributor.author | Rodríguez-Fuster, Alberto |
dc.contributor.author | Aguiló Espases, Rafael |
dc.contributor.author | Barreiro Portela, Esther |
dc.date.accessioned | 2020-09-18T07:13:17Z |
dc.date.available | 2020-09-18T07:13:17Z |
dc.date.issued | 2020 |
dc.identifier.citation | Tang J, Ramis-Cabrer D, Curull V, Wang X, Qin L, Mateu-Jiménez M. et al. Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD. Cancers (Basel). 2020 May 13; 12(5):1217. DOI: 10.3390/cancers12051217 |
dc.identifier.issn | 2072-6694 |
dc.identifier.uri | http://hdl.handle.net/10230/45314 |
dc.description.abstract | Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by T regulatory (Treg), natural killer (NK), and plasma cells, as well as interleukin (IL)-10 and interferon-gamma, may differ within tumors of LC patients with/without COPD. Methods: Treg (anti-CD3 and anti-forkhead boxP3 antibodies), NK (anti-NCR1 antibody), IgG (anti-CD138-IgG antibody), IgA (anti-CD138-IgA antibody) using immunohistochemistry, and both IL-10 and interferon-gamma (ELISA) were quantified in tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 33 LC-COPD patients and 20 LC-only patients. Results: Immune profile in tumor versus non-tumor specimens: Treg cell counts significantly increased in tumors of both LC and LC-COPD patients, while in tumors of the latter group, IgG-secreting plasma cells significantly decreased and IL-10 increased. No significant differences were seen in levels of NK cells, IgA-secreting cells, IgA/IgG, or interferon-gamma. Immune profile in tumors of LC-COPD versus LC: No significant differences were observed in tumors between LC-COPD and LC patients for any study marker. Conclusions: Immune cell subtypes and cytokines are differentially expressed in lung tumors, and the presence of COPD elicited a decline in IgG-secreting plasma cell levels but not in other cell types. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | MDPI |
dc.relation.ispartof | Cancers (Basel). 2020 May 13;12(5):1217 |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.title | Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.3390/cancers12051217 |
dc.subject.keyword | COPD |
dc.subject.keyword | IL-10 and interferon-gamma |
dc.subject.keyword | T regulatory cells |
dc.subject.keyword | Immune tumor microenvironment |
dc.subject.keyword | Lung cancer |
dc.subject.keyword | Natural killer cells |
dc.subject.keyword | Immunoglobulin-secreting plasma cells |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |