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Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup

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dc.contributor.author Alonso Martínez, Sonsoles
dc.contributor.author Marsman, Jan-Bernard C.
dc.contributor.author Kringelbach, Morten L.
dc.contributor.author Deco, Gustavo
dc.contributor.author ter Horst, Gert J.
dc.date.accessioned 2020-07-08T08:35:13Z
dc.date.available 2020-07-08T08:35:13Z
dc.date.issued 2020
dc.identifier.citation Alonso Martínez S, Marsman JBC, Kringelbach ML, Deco G, ter Horst GJ. Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup. Neuroimage Clin. 2020 May 26;27:102299. DOI: 10.1016/j.nicl.2020.102299
dc.identifier.issn 2213-1582
dc.identifier.uri http://hdl.handle.net/10230/45088
dc.description.abstract Depressive symptoms following a stressful life event, such as a relationship breakup, are common, and constitute a potent risk factor for the onset of a major depressive episode. Resting-state neuroimaging studies have increasingly identified abnormal whole-brain communication in patients with depression, but it is currently unclear whether depressive symptoms in individuals without a clinical diagnosis have reliable neural underpinnings. We investigated to what extent the severity of depressive symptoms in a non-clinical sample was associated with imbalances in the complex dynamics of the brain during rest. To this end, a novel intrinsic ignition approach was applied to resting-state neuroimaging data from sixty-nine participants with varying degrees of depressive symptoms following a relationship breakup. Ignition-based measures of integration, hierarchy, and metastability were calculated for each participant, revealing a negative correlation between these measures and depressive ratings. We found that the severity of depressive symptoms was associated with deficits in the brain’s capacity to globally integrate and process information over time. Furthermore, we found that increased depressive symptoms were associated with reduced spatial diversity (i.e., hierarchy) and reduced temporal variability (i.e., metastability) in the functional organization of the brain. These findings suggest the merit of investigating constrained dynamical complexity as it is sensitive to the level of depressive symptoms even in a non-clinical sample.
dc.description.sponsorship This work was funded by a donation of Mr. Hazewinkel to Prof. dr. Gert J. ter Horst and the Research School of Behavioural and Cognitive Neurosciences, University of Groningen, the Netherlands. The funder had no role in study design, the collection, analysis and, interpretation of data, the decision to publish, or the writing of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof NeuroImage: clinical. 2020 May 26;27:102299
dc.rights © 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
dc.title Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.nicl.2020.102299
dc.subject.keyword Resting-state fMRI
dc.subject.keyword Global integration
dc.subject.keyword Spatiotemporal dynamics
dc.subject.keyword Whole-brain
dc.subject.keyword Depressive symptoms
dc.subject.keyword Non-clinical sample
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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