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Genetic affinities of an eradicated European Plasmodium falciparum strain

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dc.contributor.author de Dios, Toni
dc.contributor.author van Dorp, Lucy
dc.contributor.author Gelabert Xirinachs, Pere, 1991-
dc.contributor.author Carøe, Christian
dc.contributor.author Sandoval Velasco, Marcela
dc.contributor.author Fregel, Rosa
dc.contributor.author Escosa, Raül
dc.contributor.author Aranda, Carles
dc.contributor.author Huijben, Silvie
dc.contributor.author Balloux, François
dc.contributor.author Gilbert, M Thomas
dc.contributor.author Lalueza Fox, Carles, 1965-
dc.date.accessioned 2020-07-07T06:31:43Z
dc.date.available 2020-07-07T06:31:43Z
dc.date.issued 2019
dc.identifier.citation de-Dios T, van Dorp L, Gelabert P, Carøe C, Sandoval-Velasco M, Fregel R, Escosa R, Aranda C, Huijben S, Balloux F, Gilbert MTP, Lalueza-Fox C. Genetic affinities of an eradicated European Plasmodium falciparum strain. Microb Genom. 2019; 5(9):e000289. DOI: 10.1099/mgen.0.000289
dc.identifier.issn 2057-5858
dc.identifier.uri http://hdl.handle.net/10230/45081
dc.description.abstract Malaria was present in most of Europe until the second half of the 20th century, when it was eradicated through a combination of increased surveillance and mosquito control strategies, together with cross-border and political collaboration. Despite the severe burden of malaria on human populations, it remains contentious how the disease arrived and spread in Europe. Here, we report a partial Plasmodium falciparum nuclear genome derived from a set of antique medical slides stained with the blood of malaria-infected patients from Spain's Ebro Delta, dating to the 1940s. Our analyses of the genome of this now eradicated European P. falciparum strain confirms stronger phylogeographical affinity to present-day strains in circulation in central south Asia, rather than to those in Africa. This points to a longitudinal, rather than a latitudinal, spread of malaria into Europe. In addition, this genome displays two derived alleles in the pfmrp1 gene that have been associated with drug resistance. Whilst this could represent standing variation in the ancestral P. falciparum population, these mutations may also have arisen due to the selective pressure of quinine treatment, which was an anti-malarial drug already in use by the time the sample we sequenced was mounted on a slide.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.relation.ispartof Microb Genom. 2019; 5(9):e000289
dc.rights © 2019 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Genetic affinities of an eradicated European Plasmodium falciparum strain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1099/mgen.0.000289
dc.subject.keyword Plasmodium falciparum
dc.subject.keyword Ancient genomics
dc.subject.keyword Drug resistance
dc.subject.keyword Malaria
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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