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A multicenter phase II RCT to compare the effectiveness of EMDR versus TAU in patients with a first-episode psychosis and psychological trauma: a protocol design

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dc.contributor.author Valiente Gómez, Alicia
dc.contributor.author Pujol, Nuria
dc.contributor.author Moreno Alcázar, Ana
dc.contributor.author Radua, Joaquim
dc.contributor.author Monteagudo-Gimeno, Eila
dc.contributor.author Gardoki-Souto, Itxaso
dc.contributor.author Hogg, Bridget
dc.contributor.author Álvarez, Maria José
dc.contributor.author Safont, Gemma
dc.contributor.author Lupo, Walter
dc.contributor.author Pérez Solá, Victor
dc.contributor.author Amann, Benedikt Lorenz
dc.contributor.author FEP-EMDR Research Group
dc.date.accessioned 2020-06-03T06:28:20Z
dc.date.available 2020-06-03T06:28:20Z
dc.date.issued 2020
dc.identifier.citation Valiente-Gómez A, Pujol N, Moreno-Alcázar A, Radua J, Monteagudo-Gimeno E, Gardoki-Souto I,et al. A multicenter phase II RCT to compare the effectiveness of EMDR versus TAU in patients with a first-episode psychosis and psychological trauma: a protocol design. Front Psychiatry. 2020 Feb 5; 10:1023. DOI: 10.3389/fpsyt.2019.01023
dc.identifier.issn 1664-0640
dc.identifier.uri http://hdl.handle.net/10230/44886
dc.description.abstract Background: Patients with a first episode psychosis (FEP) who are admitted for the first time to a psychiatric hospital frequently have experienced prior psychological trauma. Additionally, 40-80% develop posttraumatic stress symptoms, which are summarized as a post-psychotic post-traumatic syndrome (PPS). Eye Movement Desensitization and reprocessing (EMDR) therapy could be an effective psychotherapy to treat a PPS and prior psychological traumas in this population. Objectives: To assess if EMDR therapy leads to: 1) a reduction of relapses after intervention, 2) an improvement of trauma-related, psychotic and affective symptoms, 3) an improvement of overall functioning, and 4) an improvement in quality of life. Methods: This is a multicenter phase II rater-blinded randomized controlled trial in which 80 FEP patients with a history of psychological trauma will be randomly assigned to EMDR (n = 40) or to TAU (n = 40). Traumatic events will be measured by the Global Assessment of Posttraumatic Stress Questionnaire, the Cumulative Trauma Screening, the Impact of Event Scale-Revised, the Dissociative Experiences Scale, the Childhood Trauma Scale, the Holmes-Rahe Life Stress Inventory, and the Dissociative Experiences Questionnaire. Clinical symptomatology will be evaluated using the Suicide and Drug Consumption module of the International Neuropsychiatric Interview, Structured Clinical Interview for Positive and Negative Syndrome Scale, Young's Scale for Mania Evaluation, and Beck Depression II Questionnaire. Functionality will be assessed with the Global Assessment of Functioning and the Quality of Life with the Standardized Instrument developed by the EuroQol Group. The cognitive insight and adherence to the treatment will be assessed with the Beck Cognitive Insight Scale and the Drug Attitude Inventory. All variables will be measured at baseline, post-treatment and at 12-month follow-up. Conclusion: This study will provide evidence of whether EMDR therapy is effective in reducing trauma and clinical symptoms, reducing relapses and in improving functionality and quality of life in patients with FEP and a history of trauma.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.rights Copyright © 2020 Valiente-Gómez, Pujol, Moreno-Alcázar, Radua, Monteagudo-Gimeno, Gardoki-Souto, Hogg, Álvarez, Safont, Lupo, Pérez, Amann and the FEP-EMDR Research Group. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title A multicenter phase II RCT to compare the effectiveness of EMDR versus TAU in patients with a first-episode psychosis and psychological trauma: a protocol design
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2019.01023
dc.subject.keyword EMDR therapy
dc.subject.keyword Comorbidity
dc.subject.keyword First episode psychosis
dc.subject.keyword Post-psychotic posttraumatic stress
dc.subject.keyword Psychological trauma
dc.subject.keyword Treatment as usual
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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