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dc.contributor.author | Havet, Anaïs |
dc.contributor.author | Li, Zhen |
dc.contributor.author | Zerimech, Farid |
dc.contributor.author | Sanchez, Margaux |
dc.contributor.author | Siroux, Valérie |
dc.contributor.author | Le Moual, Nicole |
dc.contributor.author | Brunekreef, Bert |
dc.contributor.author | Künzli, Nino |
dc.contributor.author | Jacquemin Leonard, Bénédicte |
dc.contributor.author | Varraso, Raphaëlle |
dc.contributor.author | Matran, Regis |
dc.contributor.author | Nadif, Rachel |
dc.date.accessioned | 2020-06-02T07:28:15Z |
dc.date.available | 2020-06-02T07:28:15Z |
dc.date.issued | 2019 |
dc.identifier.citation | Havet A, Li Z, Zerimech F, Sanchez M, Siroux V, Le Moual N, Brunekreef B, Künzli N, Jacquemin B, Varraso R, Matran R, Nadif R. Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study. Environ Health. 2019; 18(1):90. DOI: 10.1186/s12940-019-0532-0 |
dc.identifier.issn | 1476-069X |
dc.identifier.uri | http://hdl.handle.net/10230/44863 |
dc.description.abstract | Background: Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma. Methods: Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003-2007) and EGEA3 (follow-up, 2011-2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM10) and ≤ 2.5 μm were estimated by ESCAPE models (2009-2010), and ozone (O3) by IFEN models (2004). We used a mediation analysis to assess the mediated effect by FlOPs levels and the interaction between FlOPs levels and air pollution. Results: FlOPs levels increased with PM10 and O3 (adjusted β = 0.04 (95%CI 0.001-0.08), aβ = 0.04 (95%CI 0.009-0.07) per 10 μg/m3, respectively), and the risk of persistent asthma increased with FlOPs levels (aOR = 1.81 (95%CI 1.08-3.02)). The risk of persistent asthma decreased with exposures to NO2, NOx and PM2.5 (aOR ranging from 0.62 to 0.94), and increased with exposures to PM10, O3, O3-summer and road traffic, the greater effect being observed for O3 (aOR = 1.78, 95% CI 0.73-4.37, per 10 μg/m3). Using mediation analysis, we observed a positive total effect (aOR = 2.16, 95%CI 0.70-11.9), a positive direct effect of O3 on persistent asthma (OR = 1.68, 95%CI 0.57-7.25), and a positive indirect effect mediated by FIOPs levels (aOR = 1.28 (95%CI 1.01-2.29)) accounting for 41% of the total effect. Conclusions: Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma. |
dc.description.sponsorship | This work was supported by the National Hospital program of clinical research [PHRC-national 2012, EvAdA]; ANR-CES-2009; Region Nord Pas-de-Calais; Merck Sharp & Dohme (MSD); the GA2LEN (Global Allergy and Asthma European Network) project; the Fonds AGIR pour les maladies chroniques and ESCAPE [FP7/2007–2011, Grant Nr.211250]. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | BioMed Central |
dc.relation.ispartof | Environ Health. 2019; 18(1):90 |
dc.rights | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.title | Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1186/s12940-019-0532-0 |
dc.subject.keyword | Epidemiology |
dc.subject.keyword | Fluorescent oxidation products |
dc.subject.keyword | Mediation analysis |
dc.subject.keyword | Outdoor air pollution |
dc.subject.keyword | Oxidative stress |
dc.subject.keyword | Persistent asthma |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/211250 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |