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Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

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dc.contributor.author Wexler, Judith
dc.contributor.author Delaney, Emily Kay
dc.contributor.author Belles, Xavier
dc.contributor.author Schal, Coby
dc.contributor.author Wada-Katsumata, Ayako
dc.contributor.author Amicucci, Matthew J.
dc.contributor.author Kopp, Artyom
dc.date.accessioned 2020-05-28T07:37:00Z
dc.date.available 2020-05-28T07:37:00Z
dc.date.issued 2019
dc.identifier.citation Wexler J, Delaney EK, Belles X, Schal C, Wada-Katsumata A, Amicucci MJ, Kopp A. Hemimetabolous insects elucidate the origin of sexual development via alternative splicing. Elife. 2019; 8:e47490. DOI: 10.7554/eLife.47490
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/44840
dc.description.abstract Insects are the only known animals in which sexual differentiation is controlled by sex-specific splicing. The doublesex transcription factor produces distinct male and female isoforms, which are both essential for sex-specific development. dsx splicing depends on transformer, which is also alternatively spliced such that functional Tra is only present in females. This pathway has evolved from an ancestral mechanism where dsx was independent of tra and expressed and required only in males. To reconstruct this transition, we examined three basal, hemimetabolous insect orders: Hemiptera, Phthiraptera, and Blattodea. We show that tra and dsx have distinct functions in these insects, reflecting different stages in the changeover from a transcription-based to a splicing-based mode of sexual differentiation. We propose that the canonical insect tra-dsx pathway evolved via merger between expanding dsx function (from males to both sexes) and narrowing tra function (from a general splicing factor to dedicated regulator of dsx).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof Elife. 2019; 8:e47490
dc.rights © 2019, Wexler et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Hemimetabolous insects elucidate the origin of sexual development via alternative splicing
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.47490
dc.subject.keyword Blattella germanica
dc.subject.keyword Development
dc.subject.keyword Developmental biology
dc.subject.keyword Doublesex
dc.subject.keyword Evolution
dc.subject.keyword Evolutionary biology
dc.subject.keyword Sex
dc.subject.keyword Transformer
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CGL2012-36251
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CGL2015-64727-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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