Welcome to the UPF Digital Repository

Upregulation of E93 gene expression acts as the trigger for metamorphosis independently of the threshold size in the beetle tribolium castaneum

Show simple item record

dc.contributor.author Chafino Aixa, Silvia, 1991-
dc.contributor.author Ureña, Enric
dc.contributor.author Casanova, Jordi
dc.contributor.author Casacuberta Suñer, Elena, 1972-
dc.contributor.author Franch i Marro, Xavier
dc.contributor.author Martín, David
dc.date.accessioned 2020-05-26T07:37:55Z
dc.date.available 2020-05-26T07:37:55Z
dc.date.issued 2019
dc.identifier.citation Chafino S, Ureña E, Casanova J, Casacuberta E, Franch-Marro X, Martín D. Upregulation of E93 gene expression acts as the trigger for metamorphosis independently of the threshold size in the beetle tribolium castaneum. Cell Rep. 2019; 27(4):1039-1049.e2. DOI: 10.1016/j.celrep.2019.03.094
dc.identifier.issn 2211-1247
dc.identifier.uri http://hdl.handle.net/10230/44808
dc.description.abstract Body size in holometabolous insects is determined by the size at which the juvenile larva undergoes metamorphosis to the pupal stage. To undergo larva-pupa transition, larva must reach a critical developmental checkpoint, the threshold size (TS); however, the molecular mechanisms through which the TS cues this transition remain to be fully characterized. Here, we use the flour beetle Tribolium castaneum to characterize the molecular mechanisms underlying entry into metamorphosis. We found that T. castaneum reaches a TS at the beginning of the last larval instar, which is associated with the downregulation of TcKr-h1 and the upregulation of TcE93 and TcBr-C. Unexpectedly, we found that while there is an association between TS and TcE93 upregulation, it is the latter that constitutes the molecular trigger for metamorphosis initiation. In light of our results, we evaluate the interactions that control the larva-pupa transition and suggest alternative models.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cell Rep. 2019; 27(4):1039-1049.e2
dc.rights © 2019 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Upregulation of E93 gene expression acts as the trigger for metamorphosis independently of the threshold size in the beetle tribolium castaneum
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2019.03.094
dc.subject.keyword E93
dc.subject.keyword Kr-h1
dc.subject.keyword Tribolium castaneum
dc.subject.keyword Broad-complex
dc.subject.keyword Ecdysone
dc.subject.keyword Growth control
dc.subject.keyword Holometaboly
dc.subject.keyword Insect metamorphosis
dc.subject.keyword Juvenile hormone
dc.subject.keyword Threshold size
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking