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Breakdown of whole-brain dynamics in preterm-born children

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dc.contributor.author Padilla, Nelly
dc.contributor.author Saenger, Victor M.
dc.contributor.author van Hartevelt, Tim J.
dc.contributor.author Fernandes, Henrique M.
dc.contributor.author Lennartsson, Finn
dc.contributor.author Andersson, Jesper L. R.
dc.contributor.author Kringelbach, Morten L.
dc.contributor.author Deco, Gustavo
dc.contributor.author Åden, Ulrika
dc.date.accessioned 2020-04-27T08:27:09Z
dc.date.available 2020-04-27T08:27:09Z
dc.date.issued 2019
dc.identifier.citation Padilla N, Saenger VM, van Hartevelt TJ, Fernandes HM, Lennartsson F, Andersson JLR, Kringelbach M, Deco G, Åden U. Breakdown of whole-brain dynamics in preterm-born children. Cereb Cortex. 2019 Aug 23;30(3):1159-70. DOI: 10.1093/cercor/bhz156
dc.identifier.issn 1047-3211
dc.identifier.uri http://hdl.handle.net/10230/44333
dc.description.abstract The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at < 27 weeks of gestation and 28 full-term controls. Two approaches were adopted in both groups, when they were 10 years of age, using structural and functional brain magnetic resonance imaging data. The first was using a novel intrinsic ignition analysis to study the ability of the areas of the brain to propagate neural activity. The second was a whole-brain Hopf model, to define the level of stability, desynchronization, or criticality of the brain. EPT-born children exhibited fewer intrinsic ignition events than controls; nodes were related to less sophisticated aspects of cognitive control, and there was a different hierarchy pattern in the propagation of information and suboptimal synchronicity and criticality. The largest differences were found in brain nodes belonging to the rich-club architecture. These results provide important insights into the neural substrates underlying brain reorganization and neurodevelopmental impairments related to prematurity.
dc.description.sponsorship Swedish Medical Research Council (grant numbers 523-2011-3981, 2017-03043); the regional agreement on medical training and clinical research (grant number, ALF SLL 20170243) between Stockholm County Council and the Karolinska Institutet; European Union Seventh Framework Project (grant number 223767); Swedish Order of Freemasons in Stockholm; Swedish Medical Society; Swedish Brain Foundation (grant number FO2017-0131); Sällskapet Barnavård; Linnèa och Josef Carlssons Stifelse’ Erik and Edith Fernström Stiftelse; Ishizu Matsumura Foundation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Cerebral Cortex. 2019 Aug 23;30(3):1159-70
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Breakdown of whole-brain dynamics in preterm-born children
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/cercor/bhz156
dc.subject.keyword Brain development
dc.subject.keyword Brain dynamics
dc.subject.keyword Functional connectivity
dc.subject.keyword Neurodevelopment
dc.subject.keyword Prematurity
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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