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Differential patterns of brain activation between hoarding disorder and obsessive-compulsive disorder during executive performance

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dc.contributor.author Suñol, Maria
dc.contributor.author Martínez-Zalacaín, Ignacio
dc.contributor.author Picó-Pérez, Maria
dc.contributor.author López-Solà, Clara
dc.contributor.author Real, Eva
dc.contributor.author Fullana Rivas, Miguel Ángel
dc.contributor.author Pujol Nuez, Jesús
dc.contributor.author Cardoner, Narcís
dc.contributor.author Menchón, José M.
dc.contributor.author Alonso, Pino
dc.contributor.author Soriano Mas, Carles
dc.date.accessioned 2020-04-01T09:13:14Z
dc.date.issued 2020
dc.identifier.citation Suñol M, Martínez-Zalacaín I, Picó-Pérez M, López-Solà C, Real E, Fullana MA, et al. Differential patterns of brain activation between hoarding disorder and obsessive-compulsive disorder during executive performance. Psychol Med. 2020 Mar;50(4):666-73. DOI: 10.1017/S0033291719000515
dc.identifier.issn 0033-2917
dc.identifier.uri http://hdl.handle.net/10230/44136
dc.description.abstract Background: Preliminary evidence suggests that hoarding disorder (HD) and obsessive-compulsive disorder (OCD) may show distinct patterns of brain activation during executive performance, although results have been inconclusive regarding the specific neural correlates of their differential executive dysfunction. In the current study, we aim to evaluate differences in brain activation between patients with HD, OCD and healthy controls (HCs) during response inhibition, response switching and error processing. Methods: We assessed 17 patients with HD, 18 patients with OCD and 19 HCs. Executive processing was assessed inside a magnetic resonance scanner by means of two variants of a cognitive control protocol (i.e. stop- and switch-signal tasks), which allowed for the assessment of the aforementioned executive domains. Results: OCD patients performed similar to the HCs, differing only in the number of successful go trials in the switch-signal task. However, they showed an anomalous hyperactivation of the right rostral anterior cingulate cortex during error processing in the switch-signal task. Conversely, HD patients performed worse than OCD and HC participants in both tasks, showing an impulsive-like pattern of response (i.e. shorter reaction time and more commission errors). They also exhibited hyperactivation of the right lateral orbitofrontal cortex during successful response switching and abnormal deactivation of frontal regions during error processing in both tasks. Conclusions: Our results support that patients with HD and OCD present dissimilar cognitive profiles, supported by distinct neural mechanisms. Specifically, while alterations in HD resemble an impulsive pattern of response, patients with OCD present increased error processing during response conflict protocols.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cambridge University Press
dc.rights © Cambridge University Press. The published version of the article: Suñol M, Martínez-Zalacaín I, Picó-Pérez M, López-Solà C, Real E, Fullana MÀ, et al. Differential patterns of brain activation between hoarding disorder and obsessive-compulsive disorder during executive performance. Psychol Med. 2020 Mar;50(4):666-73. is available at https://www.cambridge.org/core/journals/psychological-medicine
dc.title Differential patterns of brain activation between hoarding disorder and obsessive-compulsive disorder during executive performance
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1017/S0033291719000515
dc.subject.keyword Brain activation
dc.subject.keyword Executive function
dc.subject.keyword Hoarding disorder
dc.subject.keyword Neuroimaging
dc.subject.keyword Obsessive-compulsive disorder
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2021-03-31
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2021-03-31

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