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Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

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dc.contributor.author Sikdar, Sinjini
dc.contributor.author Vives Usano, Marta, 1990-
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author London, Stephanie J.
dc.date.accessioned 2020-03-20T07:46:15Z
dc.date.available 2020-03-20T07:46:15Z
dc.date.issued 2019
dc.identifier.citation Sikdar S, Joehanes R, Joubert BR, Xu CJ, Vives-Usano M, Rezwan FI et al. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics. 2019; 11(13):1487-500. DOI: 10.2217/epi-2019-0066
dc.identifier.issn 1750-1911
dc.identifier.uri http://hdl.handle.net/10230/43964
dc.description.abstract Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Future Medicine
dc.relation.ispartof Epigenomics. 2019; 11(13):1487-500
dc.rights © 2019 Sinjini Sikdar. Open access. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.2217/epi-2019-0066
dc.subject.keyword Cigarette smoking
dc.subject.keyword Epigenetics
dc.subject.keyword Infant
dc.subject.keyword Maternal exposure
dc.subject.keyword Methylation
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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