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Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats

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dc.contributor.author Vázquez, Alejandra
dc.contributor.author Sánchez-Rodriguez, Estefanía
dc.contributor.author Vargas, Félix
dc.contributor.author Montoro-Molina, Sebastián
dc.contributor.author Romero-Cuevas, Miguel
dc.contributor.author Espejo, Juan-Antonio
dc.contributor.author Vilchez, Pedro
dc.contributor.author Jaramillo, Sara
dc.contributor.author Olmo-García, Lucía
dc.contributor.author Carrasco-Pancorbo, Alegría
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Martínez de Victoria, Emilio
dc.contributor.author Mesa, Maria-Dolores
dc.date.accessioned 2020-03-20T07:44:21Z
dc.date.available 2020-03-20T07:44:21Z
dc.date.issued 2019
dc.identifier.citation Vazquez A, Sanchez-Rodriguez E, Vargas F, Montoro-Molina S, Romero M, Espejo-Calvo JA, et al. Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats. Nutrients. 2019 Jul 26; 11(8). pii: E1728. DOI: 10.3390/nu11081728
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/43962
dc.description.abstract Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in spontaneously hypertensive rats (SHR). Thirty SHR were randomly assigned to three groups: a control untreated SHR group, an SHR group (1 mL/rat/day) of a control olive oil (17.6 mg/kg of phenolic compounds), and an SHR group (1 mL/rat/day) of the enriched EVOO (750 mg/kg of phenolic compounds) for eight weeks. Ten Wistar Kyoto rats (WKY) were included as healthy controls. Long-term administration of the enriched EVOO decreased systolic blood pressure and cardiac hypertrophy, and improved the ex vivo aortic endothelial dysfunction measured in SHR. Moreover, enriched oil supplementation reduced the plasma levels of Angiotensin II and total cholesterol, and the urinary levels of endothelin-1 and oxidative stress biomarkers, while pro-inflammatory cytokines were unaffected. In conclusion, sustained treatment with EVOO, enriched in bioactive compounds from the olive fruit and leaves, may be an effective tool for reducing blood pressure and cholesterol levels alone or in combination with pharmacological anti-hypertensive treatment.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu11081728
dc.subject.keyword Endothelial function
dc.subject.keyword Extra virgin olive oil
dc.subject.keyword Hypertension
dc.subject.keyword Phenolic compounds
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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